About: Recombinant Attenuated Salmonella typhimurium Expressing IL-2     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Recombinant Attenuated Salmonella typhimurium Expressing IL-2
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
  • Bacterium
Preferred_Name
  • Recombinant Attenuated Salmonella typhimurium Expressing IL-2
NCI_META_CUI
  • CL421482
PDQ_Open_Trial_Search_ID
  • 672505
PDQ_Closed_Trial_Search_ID
  • 672505
FULL_SYN
  • Recombinant Attenuated Salmonella typhimurium Expressing IL-2PTNCI
DEFINITION
  • An orally available, genetically engineered Salmonella typhimurium strain expressing a truncated form of the human cytokine interleukin-2 (IL-2) gene, with antitumor activity. Upon administration of recombinant attenuated S. typhimurium expressing IL-2 (SalpIL2), this Salmonella strain may selectively accumulate and divide in a variety of tumor types, and express IL-2. In turn, IL-2 may induce natural killer (NK) cell proliferation thereby enhancing their activity. This may inhibit the growth of tumor cells.NCI
code
  • C91096
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