About: Zopiclone     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Zopiclone
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Zopiclone
UMLS_CUI
  • C0078847
CAS_Registry
  • 43200-80-2
FDA_UNII_Code
  • 03A5ORL08Q
Contributing_Source
  • FDA
Chemical_Formula
  • C17H17ClN6O3
Legacy_Concept_Name
  • Zopiclone
CHEBI_ID
  • CHEBI:32315
FULL_SYN
  • 1-Piperazinecarboxylic acid, 4-methyl-, 6-(5-chloro-2-pyridinyl)-6,7-dihydro-7-oxo-5H-pyrrolo(3,4-b)pyrazin-5-yl EsterSNNCI
  • 6-(5-chloropyrid-2-yl)-5-(4-methylpiperazin-1-yl)carbonyloxy-7-oxo-6,7-dihydro-5H-pyrrolo(3,4-b)pyrazineSNNCI
  • (+-)-ZopicloneSYNCI
  • ZOPICLONEPTFDA03A5ORL08Q
  • AmobanBRNCI
  • RP 27267CNNCI
  • ZopiclonePTNCI
DEFINITION
  • The racemic form of a nonbenzodiazepine, cyclopyrrolone with hypnotic and sedative activity and without significant anxiolytic activity. Although the exact mechanism of action remains to be fully elucidated, zopiclone is able to bind to and activate the omega-1 subtype of the alpha subunit of the gamma-aminobutyric acid-benzodiazepine GABA receptor complex (GABA-A), a chloride ionophore complex in the central nervous system (CNS). This leads to the opening of chloride channels, causing hyperpolarization, inhibition of neuronal firing, and enhancement of the inhibitory effect of GABA. This eventually leads to a hypnotic effect and allows for an induction of sleep.NCI
code
  • C80279
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