About: Obatoclax Mesylate     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Obatoclax Mesylate
rdfs:subClassOf
Has_Free_Acid_Or_Base_Form
Has_Target
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Obatoclax Mesylate
UMLS_CUI
  • C1831948
CAS_Registry
  • 803712-79-0
FDA_UNII_Code
  • 39200FJ43J
Contributing_Source
  • FDA
ALT_DEFINITION
  • A substance being studied in the treatment of several types of cancer. It is a form of obatoclax, which blocks the activity of certain proteins needed for cells to live and may cause tumor cells to die. It is a type of apoptosis inducer.NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 504100
PDQ_Closed_Trial_Search_ID
  • 504100
Chemical_Formula
  • C20H19N3O.CH4O3S
Legacy_Concept_Name
  • Obatoclax_Mesylate
FULL_SYN
  • 2-(2-[(3,5-Dimethyl-1H-pyrrol-2-yl)methylidene]-3-methoxy-2H-pyrrol-5-yl)-1H-indole MonomethanesulfonateSNNCI
  • obatoclax mesylatePTNCI-GLOSSCDR0000597162
  • Obatoclax MesylatePTNCI
  • OBATOCLAX MESYLATEPTFDA39200FJ43J
  • GX15-070MSCNNCI
DEFINITION
  • The mesylate salt of obatoclax, a synthetic small-molecule inhibitor of the bcl-2 family of proteins with potential pro-apoptotic and antineoplastic activities. Obatoclax binds to members of the Bcl-2 protein family, preventing the binding of these anti-apoptotic proteins to the pro-apoptotic proteins Bax and Bak and so promoting the activation of the apoptotic pathway in Bcl-2-overexpressing cells. The Bcl-2 family of proteins (bcl-2, bcl-xl, bcl-w, and Mcl-1) are overexpressed in a wide variety of cancers, including those of the lymphatic system, breast, lung, prostate, and colon.NCI
code
  • C62771
is Has_Salt_Form of
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