About: Bcr-Abl (b2a2)-Derived Peptide Vaccine     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Bcr-Abl (b2a2)-Derived Peptide Vaccine
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Bcr-Abl (b2a2)-Derived Peptide Vaccine
UMLS_CUI
  • C1831816
PDQ_Open_Trial_Search_ID
  • 484895
PDQ_Closed_Trial_Search_ID
  • 484895
Legacy_Concept_Name
  • Bcr-Abl_b2a2_Derived_Peptide_Vaccine
FULL_SYN
  • Bcr-Abl (b2a2)-Derived Peptide VaccinePTNCI
  • CML-VAX B2CNNCI
DEFINITION
  • A peptide vaccine consisting of the bcr-abl b2a2 fusion oncoprotein, frequently expressed in chronic myelogenous leukemia (CML), with potential antineoplastic activity. Vaccination with the bcr-abl (b2a2)-derived peptide vaccine may stimulate the host immune system to mount a cytotoxic T lymphocyte (CTL) response against tumor cells that express the bcr-abl b2a2 fusion protein. Fusion genes in CML typically result from the fusion of either BCR exon b2 or BCR exon b3 to ABL exon a2, a 'b3a2' or a 'b2a2' fusion.NCI
code
  • C61309
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