About: Imidazole-Pyrazole     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Imidazole-Pyrazole
rdfs:subClassOf
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Imidazole-Pyrazole
NSC_Code
  • 51143
UMLS_CUI
  • C0045368
Legacy_Concept_Name
  • Pyrazole_Imidazole
FULL_SYN
  • 2,3-Dihydro-1H-imidazo(1,2-b)pyrazoleSNNCI
  • IMPYABNCI
  • ImidazolepyrazoleSYNCI
  • Imidazole-PyrazolePTNCI
  • BRN 0742753CNNCI
DEFINITION
  • A synthetic agent, also known as IMPY, with antineoplastic properties. IMPY inhibits ribonucleotide reductase, an enzyme that converts ribonucleotides to deoxyribonucleotides during DNA synthesis; this agent specifically binds the smaller, nonheme-iron subunit of the enzyme. (NCI04)NCI
DesignNote
  • Inhibits the nonheme-iron subunit of ribonucleotide reductase
code
  • C29344
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