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| Description
| - The aim is to improve our understanding of physiological and pathophysiological processes on molecular, cellular, organ and whole-body levels to increase our knowledge of theoretical basis of human medicine. Molecular and cellular physiology will focus on the relationship between structure and function of key regulatory molecules, metabolism, bioenergetics, membrane transport, rapid signal transduction and their genetic determination. At the level of organ and system physiology the Institute will investigate developmental aspects and causes of obesity, atherosclerosis and hypertension. Further attention will be paid to the function of cardiovascular system, to mechanisms and consequences of early brain damage and to integrative function of neural system. The obtained results will contribute to the elucidation of pathogenesis of important human metabolic, cardiovascular and neural diseases in order to improve their diagnostics and to search for new therapeutic and prevention approaches. (en)
- Cílem výzkumu je získávat nové poznatky o fyziologických a patofyziologických procesech na úrovni molekulární, buněčné, orgánové i celého organismu směřující k prohloubení znalostí teoretických základů humánní medicíny. Na úrovni molekulární a buněčné fyziologie bude studován vztah mezi strukturou a funkcí klíčových regulačních molekul, látková přeměna a energetický metabolismus buněk, transportní funkce buněčných membrán, mechanismy rychlého přenosu signálů mezi buňkami a uvnitř buněk a genetická determinace těchto funkcí. Na úrovni orgánové a systémové bude ústav zkoumat vývojové aspekty příčiny vzniku obezity, aterosklerózy a hypertenze a dále funkci srdce a oběhového systému a integrativní funkce nervové soustavy. Výsledky přispějí k objasnění patogeneze závažných metabolických, kardiovaskulárních a nervových onemocnění člověka s cílem zlepšit jejich diagnostiku a hledat nové cesty účinné terapie a prevence.
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| Title
| - Výzkum molekulárních a buněčných základů fyziologických a patofyziologických procesů s cílem objasnit mechanismy vzniku závažných onemocnění člověka
- Investigation of molecular and cellular basis of physiological and pathophysiological processes in order to clarify the pathogenesis of important human diseases (en)
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| http://linked.open...kovaStatniPodpora
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| http://linked.open...ez/celkoveNaklady
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| http://linked.open...datumDodatniDoRIV
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| http://linked.open...vavai/cez/dodavka
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| http://linked.open...ez/duvernostUdaju
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| http://linked.open...in/vavai/cez/faze
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| http://linked.open...ai/cez/hlavniObor
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| http://linked.open...vai/cez/hodnoceni
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| http://linked.open.../cez/kategorieVaV
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| http://linked.open.../cez/klicovaSlova
| - bioenergetics; biorhythms; epilepsy; genetics; hypertension; ion channels; membrane transport; metabolic syndrome; mitochondria; neural tissue; memory; myocardial resistance; obesity; ontogeny; pain; regulatory molecules; signal transduction; vessels (en)
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| http://linked.open...cez/partnerHlavni
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| http://linked.open...z/poceVysledkuRIV
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| http://linked.open...inujicichPrijemcu
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| http://linked.open...cez/pocetPrijemcu
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| http://linked.open...ocetSpoluPrijemcu
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| http://linked.open...enychVysledkuVRIV
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| http://linked.open...lneniVMinulemRoce
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| http://linked.open.../prideleniPodpory
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| http://linked.open.../vavai/cez/resort
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| http://linked.open...iciPoslednihoRoku
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| http://linked.open...atUdajeProjZameru
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| http://linked.open...usZobrazovaneFaze
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| http://linked.open...ez/ukonceniReseni
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| http://linked.open...ez/zahajeniReseni
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| http://linked.open...n/vavai/cez/zamer
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| http://linked.open...sledkuDodavatelem
| - Results significantly contributed to understanding mechanisms and function of physiological systems in normal and pathological conditions, mainly in nervous and cardiovascular systems, energy metabolism/obesity and physiological genomics. The results, some with potential application, e.g. in drug development, were published in more than 900 papers. (en)
- Výsledky výrazně přispěly k poznání mechanismů a funkcí fyziologických systémů v normě a za patologických stavů, zejména v oblasti studia nervového a kardiovaskulárního systému, energetického metabolismu/obezity a fyziologické genomiky. Výsledky, z nichž některé mají aplikační potenciál, např. při vývoji léčiv, byly publikovány ve více než 900 pracech. (cs)
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| http://linked.open...cez/zivotniCyklus
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| is http://linked.open...n/vavai/riv/zamer
of | - Early caffeine exposure: Transient and long-term consequences on brain excitability
- Kinetics of neurotransmitter release in neuromuscular synapses of newborn and adult rats
- Molecular Mechanisms of Methoctramine Binding and Selectivity at Muscarinic Acetylcholine Receptors
- MSB 2010. 25 th International Symposium on Microscale BioSeparations
- NEURONAL AND NETWORK DYNAMICS PRECEDING EXPERIMENTAL SEIZURES
- Epileptic Focus and Alteration of Metabolism
- Effect of 7-nitroindazole, a neuronal nitric oxide synthase inhibitor, on behavioral and physiological parameters
- Long-Term Activation upon Brief Exposure to Xanomleline Is Unique to M1 and M4 Subtypes of Muscarinic Acetylcholine Receptors
- Maladaptive Myocardial Responses to Hypertension are Attenuated by Omega-3 Fatty Acids and Red Palm Oil Intake
- Studentský den 2008
- Rekombinantní protein potkaního vaniloidního receptoru podtypu 1 (TRPV1) s funkčně ověřenou trojitou mutací odstraňující cysteinové zbytky exponované vnějšímu prostředí 3CYS-TRPV1
- Rekombinantní protein potkaního vaniloidního receptoru podtypu 1 (TRPV1) s funkčně ověřenou mutací Cdelta42 zkracující délku karboxylového konce, zvyšující aktivitu receptorového kanálu vyvolanou chemickými i tepelnými podněty
- Program PMR - monitorování a záznam tlaku krve v srdci
- Workshop NanoBio 2006
- Zařízení pro snímání elektrické aktivity srdce malých hlodavců
- Impairment of iodine and thyroid hormones metabolism in very premature infants
- Autocrine effects of visfatin on hepatocyte sensitivity to insulin action.
- Mechanisms participating in oxidative damage of isolated rat hepatocytes
- Spatial Choices of Macaque Monkeys Based on the Visual Representation of the Response Space: Rotation of the Stimuli
- Glucocorticoid availability in colonic inflammation of rat
- Similar Effects of Lamotrigine and Phenytoin against Cortical Epileptic Foci in Immature Rats
- Kognitivní funkce makaků: mentální transformace geometrických stimulů
- Orientation, anisotropy, clustering, and volume fraction of smooth muscle cells within the wall of porcine abdominal aorta
- Nanocomposite Ti/hydrocarbon plasma polymer films from reactive magnetron sputtering as growth supports for osteoblast-like and endothelial cells
- 14-3-3 Protein Masks the DNA Binding Interface of Forkhead Transcription Factor FOXO4
- Economy-wide material flow indicators in the Czech Republic: trends, decoupling analysis and uncertainties
- Risperidone and ritanserin but not haloperidol block effect of dizocilpine on the active allothetic place avoidance task
- Type I iodothyronine 5-deiodinase mRNA and activity is increased in adipose tissue of obese subjects
- Toxicity study of antimicrobial peptides from wild bee venom and their analogs toward mammalian normal and cancer cells
- A Resurrection of 7-MEOTA: A Comparison with Tacrine
- 3 alpha 5 beta-Pregnanolone glutamate, a use-dependent NMDA antagonist, reversed spatial learning deficit in an animal model of schizophrenia
- Behavioral, neurochemical and pharmaco-EEG profiles of the psychedelic drug 4-bromo-2,5-dimethoxyphenethylamine (2C-B) in rats
- Brief Daily Episode of Normoxia Inhibits Cardioprotection Conferred by Chronic Continuous Hypoxia. Role of Oxidative Stress and BKCa Channels
- Are morphologic and functional consequences of status epilepticus in infant rats progressive?
- Dentate gyrus progenitor cell proliferation after the onset of spontaneous seizures in the tetanus toxin model of temporal lobe epilepsy
- Detection of pinworm eggs in the dust of laboratory animals breeding facility, in the cages and on the hands of the technicians
- Derivatives of valproic acid are active against pentetrazol-induced seizures in immature rats
- Effect of an inhibitor of neuronal nitric oxide synthase 7-nitroindazole on cerebral hemodynamic response and brain excitability in urethane-anesthetized rats
- Effects of caffeine on cortical epileptic afterdischarges in adult rats are modulated by postnatal treatment
- Mental transformations of spatial stimuli in humans and in monkeys: Rotation vs. translocation
- Multiple Cholinergic Signaling Pathways in Pituitary Gonadotrophs
- Multiple Roles of the Extracellular Vestibule Amino Acid Residues in the Function of the Rat P2X4 Receptor
- Pharmacological activation of mitochondrial BKCa channels protects isolated cardiomyocytes against simulated reperfusion-induced injury
- Parametric inference of neuronal response latency in presence of a background signal
- Place avoidance tasks as tools in the behavioral neuroscience of learning and memory
- Oxidative stress in immature brain following experimentally-induced seizures
- Salt and oxidative stress tolerance in Debaryomyces hansenii and Debaryomyces fabryi
- Fullerene C-60 and hybrid C-60/Ti films as substrates for adhesion and growth of bone cells
- Fullerene C60 films of continuous and micropatterned morphology as substrates for adhesion and growth of bone cells
- The C-Terminal Segment of Yeast BMH Proteins Exhibits Different Structure Compared to Other 14-3-3 Protein Isoforms
- Regionally-selective cell colonization of micropatterned surfaces prepared by plasma polymerization of acrylic acid and 1,7-octadiene
- Fibroblast Growth Factor-2 regulates proliferation of cardiac myocytes in normal and hypoplastic left ventricles in the developing chick
- Pregnenolone sulfate modulation of N-methyl-d-aspartate receptors is phosphorylation dependent
- A new epigenetic marker: The replication-coupled, cell cycle-dependent, dual modification of the histone H4 tail
- Separation of tryptic peptides of native and glycated BSA using open-tubular CEC with salophene-lanthanide-Zn2+ complex as stationary phase
- Endothelial cells on PET vascular prostheses impregnated with polyester-based copolymers and coated with cell-adhesive protein assemblies
- Micro-and nanopatterned surfaces for guided adhesion, growth and phenotypic maturation of cells
- Expression of the Hippocampal NMDA Receptor GluN1 Subunit and Its Splicing Isoforms in Schizophrenia: Postmortem Study
- HIF and reactive oxygen species regulate oxidative phosphorylation in cancer
- Development of a human mitochondrial oligonucleotide microarray (h-MitoArray) and gene expression analysis of fibroblast cell lines from 13 patients with isolated F1Fo ATP synthase deficiency
- DISP3, a sterol-sensing domain-containing protein that links thyroid hormone action and cholesterol metabolism
- Optimalization of immunogold labeling on thin resin sections after cryofixation
- Probing filamentarity of nuclear skeletal structures by methods of spatial statistics, mathematical morphology and image analysis
- Chromatin position in human HepG2 cells: Although being non-random, significantly changed in daughter cells
- Transcription-dependent rearrangements of actin and nuclear myosin I in the nucleolus
- Structure of the human FOXO4-DBD-DNA complex at 1.9 A resolution reveals new details of FOXO binding to the DNA
- The adhesion and growth of vascular smooth muscle cells in cultures on carboranethiol-modified gold films
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