About: Center for Cell Therapy and Tissue Repair

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Projekt, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	http://linked.opendata.cz/ontology/domain/vavai/Projekt
rdfs:seeAlso	http://www.isvav.cz/projectDetail.do?rowId=1M0538
Description	Cell therapy provides an alternative treatment for degenerative and civilization-related diseases, including neurological. The aim of cell therapy, especially using stem cells, is to replace, repair and improve the function of damaged tissue. We will achthis aim by implanting cells into a target organ in sufficient numbers and quality to initiate functional recovery. Biocompatible hydrogels and their ability to support the recovery of damaged tissue and to increase the possibility ofregeneration forms an integral part of the project. Our aim is to perform preclinical tests and to introduce the methods used into clinical practice. (en) Buněčná terapie je alternativou pro léčení degenerativních a civilizačních chorob, včetně nervových. Cílem buněčné terapie, zvl. pomocí kmenových buněk, je nahradit, opravit a zlepšit funkci poškozené tkáně. Toho chceme dosáhnout pomocí implantaceizolovaných a dobře charakterizovaných buněk do cílového orgánu v dostatečném počtu a kvalitě tak, aby byly schopny navodit návrat funkce. Součástí projektu je výzkum biokompatibilních hydrogelů a jejich schopností podpořit obnovu a nahradit poškozenoutkáň a zvýšit možnost regenerace. Cílem projektu je provedení klinických zkoušek a uplatnit oveřené postupy pro užití v klinické praxi.
Title	Center for Cell Therapy and Tissue Repair (en) Centrum buněčné terapie a tkáňových náhrad
skos:notation	1M0538
http://linked.open...avai/cep/aktivita	The research centres (National research program)
http://linked.open...kovaStatniPodpora	http://linked.opendata.cz/resource/domain/vavai/projekt/1M0538/celkovaStatniPodpora
http://linked.open...ep/celkoveNaklady	http://linked.opendata.cz/resource/domain/vavai/projekt/1M0538/celkoveNaklady
http://linked.open...datumDodatniDoRIV	2012-07-03 (xsd:date)
http://linked.open...i/cep/druhSouteze	VS - Veřejná soutěž ve výzkumu a vývoji
http://linked.open...ep/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open.../cep/fazeProjektu	91900342
http://linked.open...ai/cep/hlavniObor	FH - Neurologie, neurochirurgie, neurovědy
http://linked.open...hodnoceniProjektu	V - Vynikající výsledky (s mezinárodním významem apod.). Zároveň byly splněny cíle a předpokládané výsledky uvedené ve smlouvě / rozhodnutí o poskytnutí podpory.
http://linked.open...vai/cep/kategorie	AP - Aplikovaný výzkum
http://linked.open.../cep/klicovaSlova	stem cells; hydrogels; polymers; injury; brain; spinal cord; nuclear magnetic resonance; embryo; hepatocytes; diabetes melittus (en)
http://linked.open...ep/partnetrHlavni	2. lékařská fakulta
http://linked.open...inujicichPrijemcu	0 (xsd:int)
http://linked.open...cep/pocetPrijemcu	1 (xsd:int)
http://linked.open...ocetSpoluPrijemcu	5 (xsd:int)
http://linked.open.../pocetVysledkuRIV	161 (xsd:int)
http://linked.open...enychVysledkuVRIV	161 (xsd:int)
http://linked.open...lneniVMinulemRoce	2011-02-03 (xsd:date)
http://linked.open.../prideleniPodpory	http://linked.opendata.cz/resource/domain/vavai/cep/prideleniPodpory/14%2F2010-31
http://linked.open...iciPoslednihoRoku	2011
http://linked.open...atUdajeProjZameru	2012
http://linked.open.../vavai/cep/soutez	SMSM2005001M1
http://linked.open...usZobrazovaneFaze	DUU
http://linked.open...ai/cep/typPojektu	P - Projekt výzkumu a vývoje financovaný ze státního rozpočtu
http://linked.open...ep/ukonceniReseni	2011-12-31 (xsd:date)
http://linked.open.../cep/vedlejsiObor	FI - Traumatologie a ortopedie FJ - Chirurgie včetně transplantologie
http://linked.open...ep/zahajeniReseni	2005-01-01 (xsd:date)
http://linked.open...jektu+dodavatelem	Results of high scientific quality were obtained in the field of cellular resources, in experimental models of cellular therapy, in the field of biomaterials and in clinical studies. Some of them were patented and/or submitted as certified methodologies. The center has significantly contributed to education of students. The objectives of the programme were achieved at a high quality level. (en) Přínosné výsledky byly získány v oblasti terapie míšních lezí, diabetu, reprodukční biologie, experimentálních modelů buněčné terapie, využití biomateriálů a v klinických studiích. Tyto výsledky byly publikovány v prestižních časopisech, některé z nich byly předmětem patentů nebo certifikovaných metodik. Centrum přispělo k výchově studentů. Cíle programu byly splněny na vysoké úrovni kvality. (cs)
http://linked.open...tniCyklusProjektu	ZBBBKBKU
http://linked.open.../cep/klicoveSlovo	stem cells brain embryo hepatocytes hydrogels nuclear magnetic resonance polymers injury spinal cord
is http://linked.open...vavai/riv/projekt of	Proteomics of neural stem cells Permanent jugular catheterization in miniature pig: treatment, clinical and pathological observations Protein signaling pathways in differentiation of neural stem cells The Minipig as an Animal Model in Biomedical Stem Cell Research Targed neural stem cell differentiation and related cell based therapy in spinal cord injury Differential Regulation of Galectin Expression/Reactivity during Wound Healing in Porcine Skin and in Cultures if Epidermal Cells with Functional Impact on Migration Synthetic poly(amino acid) hydrogels with incorporated cell-adhesion peptides for tissue engineering Poly(HEMA) hydrogels with controlled pore architecture for tissue regeneration applications Poly(2-hydroxyethyl methacrylate) emboli with increased haemostatic effect for correction of haemorrhage of complex origin in endovascular surgery of children Cultivation of human keratinocytes without feeder cells on polymer carriers containing ethoxyethyl methacrylate: in vitro study Investigation of chromatographic behavior and porous properties of butyl methacrylate monolithic columns Porous Hydrogels Acute and delayed implantation of positively charged HEMA scaffolds in spinal cord injury in the rat Extracellular space diffusion and extrasynaptic transmission Clinical implications of a close vicinity of nervus dorsalis penis/clitoridis and os pubis Diffusion in brain extracellular space Pathological potential of astroglia Rapid but not slow spinal cord compression elicits neurogenic pulmonary edema in the rat Differential calcium signalling in neuronal-glial networks Properties and growth of human bone marrow mesenchymal stromal cells cultivated in different media Atropine may prevent the development of neurogenic pulmonary edema The role of nitric oxide in the development of neurogenic pulmonary edema in spinal cord-injured rats: the effect of preventive interventions Metabolic changes in the rat brain after a photochemical lesion treated by stem cell transplantation assessed by 1H MRS Macroporous hydrogels based on 2-hydroxyethyl methacrylate. Part 6: 3D hydrogels with positive and negative surface charges and polyelectrolyte complexes in spinal cord injury repair A Complex Role for FGF-2 in Self-Renewal, Survival, and Adhesion of Human Embryonic Stem Cells Measuring diffusion parameters in the brain: comparing the real-time iontophoretic method and diffusion-weighted magnetic resonance Impact of Global Cerebral Ischemia on K(+) Channel Expression and Membrane Properties of Glial Cells in the Rat Hippocampus Analysis of in vitro and in vivo characteristics of human embryonic stem cell-derived neural precursors Poly (L-lysine)-modified iron oxide nanoparticles for stem cell labeling Monitoring the survival of islet transplants by MRI using a novel technique for their automated detection and quantification Bral1: Its role in diffusion barrier formation and conduction velocity in the CNS HPMA-RGD hydrogels seeded with mesenchymal stem cells improve functional outcome in chronic spinal cord injury Vascularization of artificial beds for pancreatic islet transplantation in a rat model Astroglial networks scale synaptic activity and plasticity Experimental reconstruction of the injured spinal cord Enzymatic degradation of the hydrogels based on synthetic poly(.alpha.-amino acid)s Fluorescent magnetic nanoparticles for biomedical applications Flt3 ligand synergizes with granulocyte-colony-stimulating factor in bone marrow mobilization to improve functional outcome after spinal cord injury in the rat Improved detection of pancreatic islets in vivo using double contrast The Interaction of Osteoblasts With Bone-Implant Materials: 1. The Effect of Physicochemical Surface Properties of Implant Materials Magnetic resonance imaging of stem cell migration Mapping of the secretome of primary isolates of mammalian cells, stem cells and derived cell lines Myocardial Morphological Characteristics and Proarrhythmic Substrate in the Rat Model of Heart Failure Due to Chronic Volume Overload Mouse 3T3 fibroblasts under the influence of fibroblasts isolated from stroma of human basal cell carcinoma acquire properties of multipotent stem cells Osteogenic Differentiation of Miniature Pig Mesenchymal Stem Cells in 2D and 3D Environment The use of galectins for the production of myofibroblasts and extracellular matrix nanofibers Transcriptomic analysis of in vivo and in vitro produced bovine embryos revealed a developmental change in cullin 1 expression during maternal-to-embryonic transition The use of oligoperoxide-coated magnetic nanoparticles to label stem cells Transplantation of Predifferentiated Adipose-Derived Stromal Cells for the Treatment of Spinal Cord Injury Biomaterials combined with cell therapy for treatment of spinal cord injury Cell transplantation for spinal cord injury Superparamagnetic nanoparticles based on iron oxides with modified surface, method of their preparation and application Functional polymer hydrogels for embryonic stem cell support

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