About: Mitochondrial complex II, a novel target for anti-cancer agents

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	With the arrival of the third millennium, in spite of unprecedented progress in molecular medicine, cancer remains as untamed as ever. The complexity of tumours, dictating the potential response of cancer cells to anti-cancer agents, has been recently highlighted in a landmark paper by Weinberg and Hanahan on hallmarks of cancer [1]. Together with the recently published papers on the complexity of tumours in patients and even within the same tumour (see below), the cure for this pathology seems to be an elusive goal. Indisputably, the strategy ought to be changed, searching for targets that are generally invariant across the landscape of neoplastic diseases. One such target appears to be the mitochondrial complex II (CII) of the electron transfer chain, a recent focus of research. We document and highlight this particularly intriguing target in this review paper and give examples of drugs that use CII as their molecular target. This article is part of a Special Issue entitled: Respiratory complex II: Role in cellular physiology and disease. (C) 2012 Elsevier B.V. All rights reserved. With the arrival of the third millennium, in spite of unprecedented progress in molecular medicine, cancer remains as untamed as ever. The complexity of tumours, dictating the potential response of cancer cells to anti-cancer agents, has been recently highlighted in a landmark paper by Weinberg and Hanahan on hallmarks of cancer [1]. Together with the recently published papers on the complexity of tumours in patients and even within the same tumour (see below), the cure for this pathology seems to be an elusive goal. Indisputably, the strategy ought to be changed, searching for targets that are generally invariant across the landscape of neoplastic diseases. One such target appears to be the mitochondrial complex II (CII) of the electron transfer chain, a recent focus of research. We document and highlight this particularly intriguing target in this review paper and give examples of drugs that use CII as their molecular target. This article is part of a Special Issue entitled: Respiratory complex II: Role in cellular physiology and disease. (C) 2012 Elsevier B.V. All rights reserved. (en)
Title	Mitochondrial complex II, a novel target for anti-cancer agents Mitochondrial complex II, a novel target for anti-cancer agents (en)
skos:prefLabel	Mitochondrial complex II, a novel target for anti-cancer agents Mitochondrial complex II, a novel target for anti-cancer agents (en)
skos:notation	RIV/86652036:_____/13:00420969!RIV14-GA0-86652036
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GAP301/10/1937), P(GAP301/12/1851), Z(AV0Z50520701)
http://linked.open...iv/cisloPeriodika	5
http://linked.open...vai/riv/dodaniDat	2014
http://linked.open...aciTvurceVysledku	Rohlena, Jakub Neužil, Jiří Klučková, Katarína
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Biotechnologický ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	88562
http://linked.open...ai/riv/idVysledku	RIV/86652036:_____/13:00420969
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Mitochondrion; Complex II; Anti-cancer agent (en)
http://linked.open.../riv/klicoveSlovo	Mitochondrion Anti-cancer agent Complex II
http://linked.open...odStatuVydavatele	NL - Nizozemsko
http://linked.open...ontrolniKodProRIV	[E581315DAD38]
http://linked.open...i/riv/nazevZdroje	Biochimica Et Biophysica Acta-Bioenergetics
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...vavai/riv/projekt	Induction of apoptosis in cancer cells by mitochondria-specific compounds; the role of respiratory complex II Mechanisms of efficient killing of cancer stem cells
http://linked.open...UplatneniVysledku	2013
http://linked.open...v/svazekPeriodika	1827
http://linked.open...iv/tvurceVysledku	Neužil, Jiří Rohlena, Jakub Dong, L. Klučková, Katarína Bezawork-Geleta, A.
http://linked.open...ain/vavai/riv/wos	000317795100003
http://linked.open...n/vavai/riv/zamer	Establishing of the Biotechnology Institute ASCR
issn	0005-2728
number of pages	13 (xsd:int)
http://bibframe.org/vocab/doi	10.1016/j.bbabio.2012.10.015

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