About: Drugs that kill cancer stem-like cells

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	A review desribes mechanisms by which a host of agents kill (or fail to kill) CSCs. The authors characterize three types of CSCs, namely, breast and prostate cancer and mesothelioma cultured as cancer cell spheres in vitro. The analysis of their stemness is then taken to a new plane by using microarray analysis and the tools of bioinformatics. The tryptophan pathway was the most activated of all pathways whose activation was common to the cancer cells studied suggesting that inhibitors of indoleamine-2,3-dioxygenase (IDO), an enzyme in the tryptophan to N-formyl kynurenin pathway, would be useful for killing CSCs. The authors then develop the principle of mitochondrial targeting by synthesizing a mitochondrially targeted vitamin E succinate [MitoVES] that crosses the mitochondrial inner membrane and acts by targeting the mitochondrial complex II. MitoVES is probably thus far the best characterized agent toxic to CSCs. Two-pronged approach to therapy, therefore, might be desirable. A review desribes mechanisms by which a host of agents kill (or fail to kill) CSCs. The authors characterize three types of CSCs, namely, breast and prostate cancer and mesothelioma cultured as cancer cell spheres in vitro. The analysis of their stemness is then taken to a new plane by using microarray analysis and the tools of bioinformatics. The tryptophan pathway was the most activated of all pathways whose activation was common to the cancer cells studied suggesting that inhibitors of indoleamine-2,3-dioxygenase (IDO), an enzyme in the tryptophan to N-formyl kynurenin pathway, would be useful for killing CSCs. The authors then develop the principle of mitochondrial targeting by synthesizing a mitochondrially targeted vitamin E succinate [MitoVES] that crosses the mitochondrial inner membrane and acts by targeting the mitochondrial complex II. MitoVES is probably thus far the best characterized agent toxic to CSCs. Two-pronged approach to therapy, therefore, might be desirable. (en)
Title	Drugs that kill cancer stem-like cells Drugs that kill cancer stem-like cells (en)
skos:prefLabel	Drugs that kill cancer stem-like cells Drugs that kill cancer stem-like cells (en)
skos:notation	RIV/86652036:_____/11:00375203!RIV12-AV0-86652036
http://linked.open...avai/riv/aktivita	Z
http://linked.open...avai/riv/aktivity	Z(AV0Z50520701)
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Truksa, Jaroslav Zobalová, Renata Prokopová, Kateřina Neužil, Jiří
http://linked.open.../riv/druhVysledku	C - Kapitola v knize
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Biotechnologický ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	195498
http://linked.open...ai/riv/idVysledku	RIV/86652036:_____/11:00375203
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Cancer stem cells; 2,3-dioxygenase; MitoVES; inhibitors of indoleamine (en)
http://linked.open.../riv/klicoveSlovo	2 3-dioxygenase Cancer stem cells MitoVES inhibitors of indoleamine
http://linked.open...ontrolniKodProRIV	[C1DEED4C12F8]
http://linked.open...i/riv/mistoVydani	Rijeka
http://linked.open...i/riv/nazevZdroje	Cancer Stem Cells Theories and Practice
http://linked.open...in/vavai/riv/obor	CE
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...v/pocetStranKnihy	442 (xsd:int)
http://linked.open...cetTvurcuVysledku	7 (xsd:int)
http://linked.open...UplatneniVysledku	2011
http://linked.open...iv/tvurceVysledku	Neužil, Jiří Dong, L. F. Prokopová, Kateřina Stantic, M. Stapelberg, M. Truksa, Jaroslav Zobalová, Renata
http://linked.open...n/vavai/riv/zamer	Establishing of the Biotechnology Institute ASCR
number of pages	18 (xsd:int)
http://purl.org/ne...btex#hasPublisher	InTech
https://schema.org/isbn	978-953-307-225-8

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