About: Mitochondrially Targeted alpha-Tocopheryl Succinate Is Antiangiogenic: Potential Benefit Against Tumor Angiogenesis but Caution Against Wound Healing

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About: Mitochondrially Targeted alpha-Tocopheryl Succinate Is Antiangiogenic: Potential Benefit Against Tumor Angiogenesis but Caution Against Wound Healing Goto Sponge NotDistinct Permalink

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Description	A plausible strategy to reduce tumor progress is the inhibition of angiogenesis. We tested the antiangiogenic potential of a mitochondrially targeted analog of alpha-tocopheryl succinate (MitoVES) with high propensity to induce apoptosis. MitoVES was found to efficiently kill proliferating endothelial cells (ECs) but not contact-arrested ECs or ECs deficient in mitochondrial DNA. It suppressed angiogenesis in vitro by inducing ROS accumulation in proliferating/angiogenic ECs. Resistance of arrested ECs was ascribed to the lower mitochondrial inner transmembrane potential compared with the proliferating ECs, thus resulting in the lower level of mitochondrial uptake of MitoVES. Shorter-chain homologs of MitoVES were less efficient in angiogenesis inhibition. MitoVES was found to suppress HER2-positive breast carcinomas in a transgenic mouse as well as inhibit tumor angiogenesis. The antiangiogenic efficacy of MitoVES was corroborated by its inhibitory activity on wound healing in vivo. A plausible strategy to reduce tumor progress is the inhibition of angiogenesis. We tested the antiangiogenic potential of a mitochondrially targeted analog of alpha-tocopheryl succinate (MitoVES) with high propensity to induce apoptosis. MitoVES was found to efficiently kill proliferating endothelial cells (ECs) but not contact-arrested ECs or ECs deficient in mitochondrial DNA. It suppressed angiogenesis in vitro by inducing ROS accumulation in proliferating/angiogenic ECs. Resistance of arrested ECs was ascribed to the lower mitochondrial inner transmembrane potential compared with the proliferating ECs, thus resulting in the lower level of mitochondrial uptake of MitoVES. Shorter-chain homologs of MitoVES were less efficient in angiogenesis inhibition. MitoVES was found to suppress HER2-positive breast carcinomas in a transgenic mouse as well as inhibit tumor angiogenesis. The antiangiogenic efficacy of MitoVES was corroborated by its inhibitory activity on wound healing in vivo. (en)
Title	Mitochondrially Targeted alpha-Tocopheryl Succinate Is Antiangiogenic: Potential Benefit Against Tumor Angiogenesis but Caution Against Wound Healing Mitochondrially Targeted alpha-Tocopheryl Succinate Is Antiangiogenic: Potential Benefit Against Tumor Angiogenesis but Caution Against Wound Healing (en)
skos:prefLabel	Mitochondrially Targeted alpha-Tocopheryl Succinate Is Antiangiogenic: Potential Benefit Against Tumor Angiogenesis but Caution Against Wound Healing Mitochondrially Targeted alpha-Tocopheryl Succinate Is Antiangiogenic: Potential Benefit Against Tumor Angiogenesis but Caution Against Wound Healing (en)
skos:notation	RIV/86652036:_____/11:00369479!RIV12-AV0-86652036
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(1M0520), P(GA204/08/0811), P(GA305/07/1008), P(GAP301/10/1937), P(KAN200520703), Z(AV0Z4055905), Z(AV0Z50110509), Z(AV0Z50520701), Z(AV0Z5052915)
http://linked.open...iv/cisloPeriodika	12
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Rohlena, Jakub Zobalová, Renata Neužil, Jiří Klučková, Katarína
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Biotechnologický ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	212714
http://linked.open...ai/riv/idVysledku	RIV/86652036:_____/11:00369479
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Analogs of alpha-tocopheryl succinate; MitoVES; inhibition of angiogenesis (en)
http://linked.open.../riv/klicoveSlovo	MitoVES Analogs of alpha-tocopheryl succinate inhibition of angiogenesis
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[592FB238D78C]
http://linked.open...i/riv/nazevZdroje	Antioxidants & Redox Signaling
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	16 (xsd:int)
http://linked.open...vavai/riv/projekt	Mechanism of ROS generation and mitochondrial permeabilization The use of ultrasound in nanomedicine Center for Applied Genomics Role of mitochondria in cardiomyocyte apoptosis during myocardial infarction: from cells to the whole animal Mechanisms of efficient killing of cancer stem cells
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	15
http://linked.open...iv/tvurceVysledku	Dong, L.-F. Hozák, Pavel Neužil, Jiří Rohlena, Jakub Houštěk, Josef Zobalová, Renata Pecinová, Alena Ledvina, Miroslav Štursa, Jan Banerjee, J. Coster, M. J. Goodwin, J. Klučková, Katarína Philimonenko, Anatoly Sen, Ch.K. Tilly, D.
http://linked.open...ain/vavai/riv/wos	000296588900002
http://linked.open...n/vavai/riv/zamer	Výzkum molekulárních a buněčných základů fyziologických a patofyziologických procesů s cílem objasnit mechanismy vzniku závažných onemocnění člověka Establishing of the Biotechnology Institute ASCR Chemical principles of selected biological phenomena in medicine and ecology Regulace a signální cesty uplatňující se v genové expresi, imunitě, onkogenezi, replikaci virů, tvorbě buněčných struktur, chování buněk, vývoji a oplození
issn	1523-0864
number of pages	13 (xsd:int)
http://bibframe.org/vocab/doi	10.1089/ars.2011.4192

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