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rdf:type
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Description
| - We used the proliferation test (E-screen assay) in MCF-7 breast cancer cells and reverse transcription quantitative polymerase chain reaction (RT-qPCR) analysis of TFF1 gene expression to analyze estrogenicity of the studied compounds. RT-qPCR has proven to be a fast and valuable molecular technique in gene expression quantification. HBCD but not TBBPA increased cell proliferation in MCF-7 cells and up-regulates TFF1 gene expression in a concentration-dependent manner. Anti-estrogen ICI 182,780 inhibits up-regulation of TFF1 by HBCD. We showed that HBCD displays estrogen-like effects on MCF-7 cells. TBBPA, on the other hand, has not shown any estrogenic effect mediated by the estrogen receptor alpha.
- We used the proliferation test (E-screen assay) in MCF-7 breast cancer cells and reverse transcription quantitative polymerase chain reaction (RT-qPCR) analysis of TFF1 gene expression to analyze estrogenicity of the studied compounds. RT-qPCR has proven to be a fast and valuable molecular technique in gene expression quantification. HBCD but not TBBPA increased cell proliferation in MCF-7 cells and up-regulates TFF1 gene expression in a concentration-dependent manner. Anti-estrogen ICI 182,780 inhibits up-regulation of TFF1 by HBCD. We showed that HBCD displays estrogen-like effects on MCF-7 cells. TBBPA, on the other hand, has not shown any estrogenic effect mediated by the estrogen receptor alpha. (en)
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Title
| - Assessing oestrogenic effects of brominated flame retardants Hexabromocyclododecane and Tetrabromobisphenol A on MCF-7 cells
- Assessing oestrogenic effects of brominated flame retardants Hexabromocyclododecane and Tetrabromobisphenol A on MCF-7 cells (en)
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skos:prefLabel
| - Assessing oestrogenic effects of brominated flame retardants Hexabromocyclododecane and Tetrabromobisphenol A on MCF-7 cells
- Assessing oestrogenic effects of brominated flame retardants Hexabromocyclododecane and Tetrabromobisphenol A on MCF-7 cells (en)
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skos:notation
| - RIV/86652036:_____/10:00356209!RIV12-AV0-86652036
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http://linked.open...avai/riv/aktivita
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http://linked.open...avai/riv/aktivity
| - P(1M06011), P(2B06151), Z(AV0Z50520701)
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http://linked.open...iv/cisloPeriodika
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http://linked.open...vai/riv/dodaniDat
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http://linked.open...aciTvurceVysledku
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http://linked.open.../riv/druhVysledku
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http://linked.open...iv/duvernostUdaju
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http://linked.open...titaPredkladatele
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http://linked.open...dnocenehoVysledku
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http://linked.open...ai/riv/idVysledku
| - RIV/86652036:_____/10:00356209
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http://linked.open...riv/jazykVysledku
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http://linked.open.../riv/klicovaSlova
| - endocrine disruptors; BRF - brominated flame retardant; MCF-7 cells; TFF1 - trefoil factor (en)
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http://linked.open.../riv/klicoveSlovo
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http://linked.open...odStatuVydavatele
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http://linked.open...ontrolniKodProRIV
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http://linked.open...i/riv/nazevZdroje
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http://linked.open...in/vavai/riv/obor
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http://linked.open...ichTvurcuVysledku
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http://linked.open...cetTvurcuVysledku
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http://linked.open...vavai/riv/projekt
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http://linked.open...UplatneniVysledku
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http://linked.open...v/svazekPeriodika
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http://linked.open...iv/tvurceVysledku
| - Elzeinová, Fatima
- Pěknicová, Jana
- Děd, Lukáš
- Dorosh, Andryi
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http://linked.open...ain/vavai/riv/wos
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http://linked.open...n/vavai/riv/zamer
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issn
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number of pages
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