About: Gene expression profiling – Clusters of possibilities

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Advances in qPCR technology allow studies of increasingly large systems .The increasing data sizes allow expression profiling both in the gene and the samples dimension results. We distinguish between exploratory and confirmatory statistical studies. we demonstrate several techniques available for exploratory studies on a system of Xenopus laevis development from egg to tadpole. Techniques include hierarchical clustering, heatmap, principal component analysis and self-organizing maps. We stress that even though exploratory studies are excellent for generating hypotheses, results have not been proven statistically significant until an independent confirmatory study has been performed. However, exploratory and confirmatory studies are intimately connected and we would like to raise that awareness among qPCR practitioners. We suggest that scientific reports should always have a hypothesis focus. Advances in qPCR technology allow studies of increasingly large systems .The increasing data sizes allow expression profiling both in the gene and the samples dimension results. We distinguish between exploratory and confirmatory statistical studies. we demonstrate several techniques available for exploratory studies on a system of Xenopus laevis development from egg to tadpole. Techniques include hierarchical clustering, heatmap, principal component analysis and self-organizing maps. We stress that even though exploratory studies are excellent for generating hypotheses, results have not been proven statistically significant until an independent confirmatory study has been performed. However, exploratory and confirmatory studies are intimately connected and we would like to raise that awareness among qPCR practitioners. We suggest that scientific reports should always have a hypothesis focus. (en)
Title	Gene expression profiling – Clusters of possibilities Gene expression profiling – Clusters of possibilities (en)
skos:prefLabel	Gene expression profiling – Clusters of possibilities Gene expression profiling – Clusters of possibilities (en)
skos:notation	RIV/86652036:_____/10:00349844!RIV11-AV0-86652036
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(IAA500520809), P(IAA500970904), Z(AV0Z50520701)
http://linked.open...iv/cisloPeriodika	4
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Kubista, Mikael Rusňáková, Vendula
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Biotechnologický ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	260306
http://linked.open...ai/riv/idVysledku	RIV/86652036:_____/10:00349844
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	qPCR; Statistical analysis; Xenopus laevis (en)
http://linked.open.../riv/klicoveSlovo	qPCR Xenopus laevis Statistical analysis
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[3F31FC6F6181]
http://linked.open...i/riv/nazevZdroje	Methods
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	8 (xsd:int)
http://linked.open...vavai/riv/projekt	Mechanisms of embryonic stem cells early differentiation MicroRNA expression during early development of Xenopus laevis and mRNA degradation
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	50
http://linked.open...iv/tvurceVysledku	Kubista, Mikael Rusňáková, Vendula Forootan, A. Bergkvist, A. Garda, J.M.A. Lindh, D. Sjogreen, B. Šindelka, R.
http://linked.open...ain/vavai/riv/wos	000276262100017
http://linked.open...n/vavai/riv/zamer	Establishing of the Biotechnology Institute ASCR
issn	1046-2023
number of pages	12 (xsd:int)

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