About: Maternal diabetes alters transcriptional programs in the developing embryo

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Maternal diabetes is a well-known risk factor for birth defects, such as heart defects and neural tube defects. The causative molecular mechanisms in the developing embryo are currently unknown, and the pathogenesis of developmental abnormalities during diabetic pregnancy is not well understood. We here report results from gene expression profiling of exposed embryos from a mouse diabetes model. In comparison to normal embryos at mid-gestation, we find significantly altered gene expression levels in diabetes-exposed embryos. Over 30% of the genes we have identified encode transcription factors and chromatin modifying proteins or components of signaling pathways that impinge on transcription. The enrichment, within the set of de-regulated genes, of those encoding transcriptional regulatory molecules provides support for the hypothesis that maternal diabetes affects specific developmental programs. Maternal diabetes is a well-known risk factor for birth defects, such as heart defects and neural tube defects. The causative molecular mechanisms in the developing embryo are currently unknown, and the pathogenesis of developmental abnormalities during diabetic pregnancy is not well understood. We here report results from gene expression profiling of exposed embryos from a mouse diabetes model. In comparison to normal embryos at mid-gestation, we find significantly altered gene expression levels in diabetes-exposed embryos. Over 30% of the genes we have identified encode transcription factors and chromatin modifying proteins or components of signaling pathways that impinge on transcription. The enrichment, within the set of de-regulated genes, of those encoding transcriptional regulatory molecules provides support for the hypothesis that maternal diabetes affects specific developmental programs. (en)
Title	Maternal diabetes alters transcriptional programs in the developing embryo Maternal diabetes alters transcriptional programs in the developing embryo (en)
skos:prefLabel	Maternal diabetes alters transcriptional programs in the developing embryo Maternal diabetes alters transcriptional programs in the developing embryo (en)
skos:notation	RIV/86652036:_____/09:00339735!RIV10-AV0-86652036
http://linked.open...avai/riv/aktivita	Z
http://linked.open...avai/riv/aktivity	Z(AV0Z50520701)
http://linked.open...iv/cisloPeriodika	274
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Pavlínková, Gabriela
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Biotechnologický ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	324903
http://linked.open...ai/riv/idVysledku	RIV/86652036:_____/09:00339735
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Diabetic embryopathy; microarray; hypoxia (en)
http://linked.open.../riv/klicoveSlovo	hypoxia Diabetic embryopathy microarray
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[1278925712F9]
http://linked.open...i/riv/nazevZdroje	B M C Genomics
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	3 (xsd:int)
http://linked.open...UplatneniVysledku	2009
http://linked.open...v/svazekPeriodika	10
http://linked.open...iv/tvurceVysledku	Pavlínková, Gabriela Kappen, C. Salbaum, M.
http://linked.open...ain/vavai/riv/wos	000268753700004
http://linked.open...n/vavai/riv/zamer	Establishing of the Biotechnology Institute ASCR
issn	1471-2164
number of pages	12 (xsd:int)

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