About: Identification of candidate genes carrying polymorphisms associated with the risk of colorectal cancer by analyzing the colorectal mutome and microRNAome

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About: Identification of candidate genes carrying polymorphisms associated with the risk of colorectal cancer by analyzing the colorectal mutome and microRNAome Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The presence of single-nucleotide polymorphisms within the 3'-untranslated regions of genes could affect the binding between a microRNA and its target, with consequences on gene expression regulation. Considering the important role of miRNAs in carcinogenesis, it is hypothesized here that these SNPs could also affect the individual risk of colorectal cancer. The results support the study hypothesis and highlight the importance of SNPs within miRNA-dependent regulatory regions. Further studies on the role exerted by NUP210 and KIAA0182 in colorectal carcinogenesis are warranted. The presence of single-nucleotide polymorphisms within the 3'-untranslated regions of genes could affect the binding between a microRNA and its target, with consequences on gene expression regulation. Considering the important role of miRNAs in carcinogenesis, it is hypothesized here that these SNPs could also affect the individual risk of colorectal cancer. The results support the study hypothesis and highlight the importance of SNPs within miRNA-dependent regulatory regions. Further studies on the role exerted by NUP210 and KIAA0182 in colorectal carcinogenesis are warranted. (en)
Title	Identification of candidate genes carrying polymorphisms associated with the risk of colorectal cancer by analyzing the colorectal mutome and microRNAome Identification of candidate genes carrying polymorphisms associated with the risk of colorectal cancer by analyzing the colorectal mutome and microRNAome (en)
skos:prefLabel	Identification of candidate genes carrying polymorphisms associated with the risk of colorectal cancer by analyzing the colorectal mutome and microRNAome Identification of candidate genes carrying polymorphisms associated with the risk of colorectal cancer by analyzing the colorectal mutome and microRNAome (en)
skos:notation	RIV/75010330:_____/12:00009862!RIV13-GA0-75010330
http://linked.open...avai/riv/aktivita	I P Z
http://linked.open...avai/riv/aktivity	I, P(GA310/07/1430), P(GAP304/10/1286), P(GP305/09/P194), Z(AV0Z50390703)
http://linked.open...iv/cisloPeriodika	19
http://linked.open...vai/riv/dodaniDat	2013
http://linked.open...aciTvurceVysledku	Vodičková, Ludmila
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Státní zdravotní ústav, příspěvková organizace
http://linked.open...dnocenehoVysledku	140282
http://linked.open...ai/riv/idVysledku	RIV/75010330:_____/12:00009862
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	colorectal cancer; microRNA; genetic polymorphisms (en)
http://linked.open.../riv/klicoveSlovo	genetic polymorphisms colorectal cancer microRNA
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[8F6B4D185137]
http://linked.open...i/riv/nazevZdroje	Cancer
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	11 (xsd:int)
http://linked.open...vavai/riv/projekt	Molecular and genetic characteristics of sporadic colorectal cancer in the Czech Republic. Polymorphisms in the MTHFR gene: susceptibility to colorectal cancer and role in the response to therapy DNA repair and sporadic colorectal cancer.
http://linked.open...UplatneniVysledku	2012
http://linked.open...v/svazekPeriodika	118
http://linked.open...iv/tvurceVysledku	Barale, R. Canzian, F. Novotný, J. Vodičková, Ludmila Gemignani, F. Landi, D. Landi, S. Naccarati, A. Pardini, B. Vodička, P. Garritano, S.
http://linked.open...ain/vavai/riv/wos	000308931900007
http://linked.open...n/vavai/riv/zamer	New biotechnologies, nanomaterials and stem cells for use in regenerative medicine
issn	0008-543X
number of pages	11 (xsd:int)
http://bibframe.org/vocab/doi	10.1002/cncr.27435

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