About: The 3T3 neutral red uptake phototoxicity test: Practical experience and implications for phototoxicity testing - the report of an ECVAM-EFPIA workshop     Goto   Sponge   NotDistinct   Permalink

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Description
  • The main objectives of the workshop were: - to present %22in use%22 experience of the pharmaceutical industry with the 3T3 Neutral Red Uptake Phototoxicity Test (3T3 NRU-PT), - to discuss why it differs from the results in the original validation exercise, - to discuss technical issues and consider ways to improve the usability of the 3T3 NRU-PT for (non-topical) pharmaceuticals, e.g., by modifying the threshold of chemical light absorption to trigger photo-toxicological testing, and by modifying technical aspects of the assay, or adjusting the criteria used to classify a positive response.
  • The main objectives of the workshop were: - to present %22in use%22 experience of the pharmaceutical industry with the 3T3 Neutral Red Uptake Phototoxicity Test (3T3 NRU-PT), - to discuss why it differs from the results in the original validation exercise, - to discuss technical issues and consider ways to improve the usability of the 3T3 NRU-PT for (non-topical) pharmaceuticals, e.g., by modifying the threshold of chemical light absorption to trigger photo-toxicological testing, and by modifying technical aspects of the assay, or adjusting the criteria used to classify a positive response. (en)
Title
  • The 3T3 neutral red uptake phototoxicity test: Practical experience and implications for phototoxicity testing - the report of an ECVAM-EFPIA workshop
  • The 3T3 neutral red uptake phototoxicity test: Practical experience and implications for phototoxicity testing - the report of an ECVAM-EFPIA workshop (en)
skos:prefLabel
  • The 3T3 neutral red uptake phototoxicity test: Practical experience and implications for phototoxicity testing - the report of an ECVAM-EFPIA workshop
  • The 3T3 neutral red uptake phototoxicity test: Practical experience and implications for phototoxicity testing - the report of an ECVAM-EFPIA workshop (en)
skos:notation
  • RIV/75010330:_____/12:00009764!RIV13-MZ0-75010330
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
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  • 183453
http://linked.open...ai/riv/idVysledku
  • RIV/75010330:_____/12:00009764
http://linked.open...riv/jazykVysledku
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  • phototoxicity; in vitro; in vivo; testing; workshop (en)
http://linked.open.../riv/klicoveSlovo
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  • US - Spojené státy americké
http://linked.open...ontrolniKodProRIV
  • [8F7400615C79]
http://linked.open...i/riv/nazevZdroje
  • Regulatory toxicology and pharmacology
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
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http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 63
http://linked.open...iv/tvurceVysledku
  • Nakamura, K.
  • Jírová, Dagmar
  • Alépée, R.
  • Barroso, J.
  • Bauer, D.
  • Ceridono, M.
  • Corvi, R.
  • DeSmedt, A.
  • Fellows, M. D.
  • Frank Nash, J.
  • Gibbs, N. K.
  • Heisler, E.
  • Jacobs, A.
  • Jones, D.
  • Kandárová, H.
  • Kasper, P.
  • Kinyamu Akunda, J.
  • Kreysa, J.
  • Krul, C.
  • Learn, D.
  • Liebsch, M.
  • Lynch, A. M.
  • Muster, W.
  • Pfannenbecker, U.
  • Phillips, G.
  • Robles, C.
  • Rogiers, V.
  • Tellner, P.
  • Vohr, H. W.
  • Wattrelos, O.
  • Wilcox, P.
  • Woods, J.
  • Wändel Liminga, U.
  • Zuang, V.
  • van de Water, F.
http://linked.open...ain/vavai/riv/wos
  • 000306885800015
issn
  • 0273-2300
number of pages
http://bibframe.org/vocab/doi
  • 10.1016/j.yrtph.2012.06.001
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