About: Exposure to iodomethane and dichloromethane associated with a confusional state

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Dichloromethane and iodomethane are colorless relatively volatile liquids, which are used as solvents in chemical manufacturing processes. The major route of exposure is via inhalation and to a lesser extent through the skin and digestive tract. Both substances are characterized by significant neurotoxic effects. A 37-year-old chemist subjected to long-term inhalation exposure to both substances had been experiencing headaches, dizziness and fatigue for about 5 years. Magnetic resonance imaging )MRI( of his brain in the acute state demonstrated the presence of a T2-hyperintense lesion in the splenium of the corpus callosum, suggestive as myelinolysis. On MRI 16 days later, the MRI changes had completely resolved and the clinical picture had improved significantly. To the best of our knowledge, this is the first published report of a case of %22reversible focal splenial lesion syndrome of the corpus callosum%22, which was likely caused by industrial toxic substances. Dichloromethane and iodomethane are colorless relatively volatile liquids, which are used as solvents in chemical manufacturing processes. The major route of exposure is via inhalation and to a lesser extent through the skin and digestive tract. Both substances are characterized by significant neurotoxic effects. A 37-year-old chemist subjected to long-term inhalation exposure to both substances had been experiencing headaches, dizziness and fatigue for about 5 years. Magnetic resonance imaging )MRI( of his brain in the acute state demonstrated the presence of a T2-hyperintense lesion in the splenium of the corpus callosum, suggestive as myelinolysis. On MRI 16 days later, the MRI changes had completely resolved and the clinical picture had improved significantly. To the best of our knowledge, this is the first published report of a case of %22reversible focal splenial lesion syndrome of the corpus callosum%22, which was likely caused by industrial toxic substances. (en)
Title	Exposure to iodomethane and dichloromethane associated with a confusional state Exposure to iodomethane and dichloromethane associated with a confusional state (en)
skos:prefLabel	Exposure to iodomethane and dichloromethane associated with a confusional state Exposure to iodomethane and dichloromethane associated with a confusional state (en)
skos:notation	RIV/75010330:_____/11:00009337!RIV12-MZ0-75010330
http://linked.open...avai/riv/aktivita	I V
http://linked.open...avai/riv/aktivity	I, V
http://linked.open...iv/cisloPeriodika	3
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Urban, Pavel
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Státní zdravotní ústav, příspěvková organizace
http://linked.open...dnocenehoVysledku	199004
http://linked.open...ai/riv/idVysledku	RIV/75010330:_____/11:00009337
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	iodomethane; dichloromethane; intoxication (en)
http://linked.open.../riv/klicoveSlovo	dichloromethane iodomethane intoxication
http://linked.open...odStatuVydavatele	NL - Nizozemsko
http://linked.open...ontrolniKodProRIV	[6D20142093D7]
http://linked.open...i/riv/nazevZdroje	NeuroToxicology
http://linked.open...in/vavai/riv/obor	FM
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	32
http://linked.open...iv/tvurceVysledku	Urban, Pavel Ehler, E. Eichlerová, A. Latta, J. Mrklovský, M.
http://linked.open...ain/vavai/riv/wos	000289925800003
issn	0161-813X
number of pages	5 (xsd:int)

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