About: Comparison of human skin irritation patch test data with in vitro skin irritation assays and animal data     Goto   Sponge   NotDistinct   Permalink

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Description
  • Efforts to replace the rabbit skin irritation test have been underway for many years, encouraged by the EU Cosmetics Directive and REACH. Recently various in vitro tests have been developed, evaluated and validated. The results confirm observations that rabbits overpredict skin effects in humans. Therefore, when validating in vitro methods, all available information, including human data, should be taken into account before making conclusions about their predictive capacity.
  • Efforts to replace the rabbit skin irritation test have been underway for many years, encouraged by the EU Cosmetics Directive and REACH. Recently various in vitro tests have been developed, evaluated and validated. The results confirm observations that rabbits overpredict skin effects in humans. Therefore, when validating in vitro methods, all available information, including human data, should be taken into account before making conclusions about their predictive capacity. (en)
Title
  • Comparison of human skin irritation patch test data with in vitro skin irritation assays and animal data
  • Comparison of human skin irritation patch test data with in vitro skin irritation assays and animal data (en)
skos:prefLabel
  • Comparison of human skin irritation patch test data with in vitro skin irritation assays and animal data
  • Comparison of human skin irritation patch test data with in vitro skin irritation assays and animal data (en)
skos:notation
  • RIV/75010330:_____/10:00008907!RIV11-MZ0-75010330
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • V
http://linked.open...iv/cisloPeriodika
  • 2
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 251452
http://linked.open...ai/riv/idVysledku
  • RIV/75010330:_____/10:00008907
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • skin irritation; skin; human epidermal model (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • US - Spojené státy americké
http://linked.open...ontrolniKodProRIV
  • [23590950B307]
http://linked.open...i/riv/nazevZdroje
  • Contact dermatitis
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 62
http://linked.open...iv/tvurceVysledku
  • Bendová, Hana
  • Jírová, Dagmar
  • Kejlová, Kristina
  • Kandárová, H.
  • Liebsch, M.
  • Basketter, D.
  • Marriott, M.
http://linked.open...ain/vavai/riv/wos
  • 000274167800006
issn
  • 0105-1873
number of pages
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