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Description
| - To characterize the human cytochrome P450 forms involved in dimemorfan oxidation (DFO), human liver microsomes, and recombinant P450s were investigated. Liquid chromatography-mass spectral analysis suggested that metabolite (M)1 ([M+H](+) m/z at 272.200) and M2 ([M+H](+) m/z at 242.190) were d-3-hydroxymethyl-N-methylmorphinan and d-3-methylmorphinan, respectively. Kinetic analyses of microsomal DFO showed that the substrate concentration showing a half-maximal velocity (S(50)) of M1 formation was less than that of M2. Microsomal M1 and M2 formation activities correlated significantly with the CYP2D6 marker, dextromethorphan O-demethylation activity. The results indicated the participation of multiple P450 forms in DFO.
- To characterize the human cytochrome P450 forms involved in dimemorfan oxidation (DFO), human liver microsomes, and recombinant P450s were investigated. Liquid chromatography-mass spectral analysis suggested that metabolite (M)1 ([M+H](+) m/z at 272.200) and M2 ([M+H](+) m/z at 242.190) were d-3-hydroxymethyl-N-methylmorphinan and d-3-methylmorphinan, respectively. Kinetic analyses of microsomal DFO showed that the substrate concentration showing a half-maximal velocity (S(50)) of M1 formation was less than that of M2. Microsomal M1 and M2 formation activities correlated significantly with the CYP2D6 marker, dextromethorphan O-demethylation activity. The results indicated the participation of multiple P450 forms in DFO. (en)
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Title
| - The oxidative metabolism of dimemorfan by human cytochrome P450 enzymes
- The oxidative metabolism of dimemorfan by human cytochrome P450 enzymes (en)
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skos:prefLabel
| - The oxidative metabolism of dimemorfan by human cytochrome P450 enzymes
- The oxidative metabolism of dimemorfan by human cytochrome P450 enzymes (en)
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skos:notation
| - RIV/75010330:_____/10:00008753!RIV11-MZ0-75010330
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http://linked.open...avai/riv/aktivita
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http://linked.open...avai/riv/aktivity
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http://linked.open...iv/cisloPeriodika
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http://linked.open...vai/riv/dodaniDat
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http://linked.open...aciTvurceVysledku
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http://linked.open.../riv/druhVysledku
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http://linked.open...iv/duvernostUdaju
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http://linked.open...titaPredkladatele
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http://linked.open...dnocenehoVysledku
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http://linked.open...ai/riv/idVysledku
| - RIV/75010330:_____/10:00008753
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http://linked.open...riv/jazykVysledku
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http://linked.open.../riv/klicovaSlova
| - metabolism; dimemorfan; cytochrome P450 (en)
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http://linked.open.../riv/klicoveSlovo
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http://linked.open...odStatuVydavatele
| - US - Spojené státy americké
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http://linked.open...ontrolniKodProRIV
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http://linked.open...i/riv/nazevZdroje
| - Journal of pharmaceutical sciences
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http://linked.open...in/vavai/riv/obor
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http://linked.open...ichTvurcuVysledku
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http://linked.open...cetTvurcuVysledku
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http://linked.open...UplatneniVysledku
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http://linked.open...v/svazekPeriodika
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http://linked.open...iv/tvurceVysledku
| - Souček, Pavel
- Chau, G.Y.
- Chi, C. W.
- Chung, Y. T.
- Liu, T.Y.
- Ueng, Y.F.
- Lee, C. H.
- Chou, Y.C.
- Gelboin, H. V.
- Krausz, K. W.
- Wang, S. Y.
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http://linked.open...ain/vavai/riv/wos
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issn
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number of pages
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