About: The CHEK2 gene I157T mutation and other alterations in its proximity increase the risk of sporadic colorectal cancer in the Czech population

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About: The CHEK2 gene I157T mutation and other alterations in its proximity increase the risk of sporadic colorectal cancer in the Czech population Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Checkpoint kinase 2 (CHEK2) gene codes for an important mediator of DNA damage response pathway. Its mutations increase risk of several types of cancer. We analysed selected CHEK2 mutations in 631 Czech colorectal cancer (CRC) patients. We conclude that the I157T and other alterations in its proximity predispose to sporadic but not to familial CRC in the Czech population. Checkpoint kinase 2 (CHEK2) gene codes for an important mediator of DNA damage response pathway. Its mutations increase risk of several types of cancer. We analysed selected CHEK2 mutations in 631 Czech colorectal cancer (CRC) patients. We conclude that the I157T and other alterations in its proximity predispose to sporadic but not to familial CRC in the Czech population. (en)
Title	The CHEK2 gene I157T mutation and other alterations in its proximity increase the risk of sporadic colorectal cancer in the Czech population The CHEK2 gene I157T mutation and other alterations in its proximity increase the risk of sporadic colorectal cancer in the Czech population (en)
skos:prefLabel	The CHEK2 gene I157T mutation and other alterations in its proximity increase the risk of sporadic colorectal cancer in the Czech population The CHEK2 gene I157T mutation and other alterations in its proximity increase the risk of sporadic colorectal cancer in the Czech population (en)
skos:notation	RIV/75010330:_____/09:00008403!RIV10-GA0-75010330
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA310/07/1430), Z(MSM0021620808)
http://linked.open...iv/cisloPeriodika	4
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Souček, Pavel Hlavatá, Ivona
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Státní zdravotní ústav, příspěvková organizace
http://linked.open...dnocenehoVysledku	306872
http://linked.open...ai/riv/idVysledku	RIV/75010330:_____/09:00008403
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Checkpoint kinase 2 (CHEK2, CHK2); colorectal cancer; germ-line mutation; genetic screening; genetic predisposition; risk assessment (en)
http://linked.open.../riv/klicoveSlovo	colorectal cancer risk assessment CHK2) genetic predisposition germ-line mutation Checkpoint kinase 2 (CHEK2 genetic screening
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[50D5A774D3F0]
http://linked.open...i/riv/nazevZdroje	European journal of cancer
http://linked.open...in/vavai/riv/obor	FD
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	7 (xsd:int)
http://linked.open...vavai/riv/projekt	Molecular and genetic characteristics of sporadic colorectal cancer in the Czech Republic.
http://linked.open...UplatneniVysledku	2009
http://linked.open...v/svazekPeriodika	45
http://linked.open...iv/tvurceVysledku	Novotný, J. Ševčík, J. Souček, Pavel Hlavatá, Ivona Kleibl, Z. Pohlreich, P. Havránek, O.
http://linked.open...ain/vavai/riv/wos	000264606100024
http://linked.open...n/vavai/riv/zamer	Molekulárně biologické, genetické a epigenetické aspekty vzniku a rozvoje modelových tumorů dospělého věku. Význam pro epidemiologii, časnou diagnostiku a léčbu
issn	0959-8049
number of pages	7 (xsd:int)

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