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| Description
| - Microemulsions have recently attracted attention as useful carriers of active substances, which offer opportunities for the encapsulation of both water-soluble and oil-soluble compounds. Due to their beneficial physico-chemical properties, they are applicable in the cosmetic, pharmaceutical and food industry. The objective of the study was to investigate the effect of various co-surfactants on the formulations of o/w microemulsions containing 1-monoacylglycerols (1-MAG) with fatty acids of different chain length, namely capric (C10:0), lauric (C12:0) and myristic (C14:0) acids. Medium-chain length alcohols (ethanol, 1-propanol, 1-butanol, 1-pentanol) were used as co-surfactants, and Tween 80 as a surfactant. Phase behaviour of the emulsion systems was studied with the help of pseudo-ternary phase diagrams, which were then used to determine final composition of microemulsions. On the optimum formulations, the size of the microemulsion droplets was determined using photon correlation spectroscopy and their antibacterial properties against the most common pathogens were studied. The results indicated that the largest region of limited miscibility was observed for microemulsions with the co-surfactant pentanol. For systems wherein ethanol, butanol and propanol were used, the reduction of immiscibility area compared with pentanol was determined. Phase diagrams proved that the area of limited miscibility for the respective 1-MAG increased with increasing chain length of the used alcohol. Regarding size, the emulsions droplets were of about 12-24 nm and the best antibacterial properties were determined on 1-MAG C12:0 microemulsions irrespective of co-surfactant used.
- Microemulsions have recently attracted attention as useful carriers of active substances, which offer opportunities for the encapsulation of both water-soluble and oil-soluble compounds. Due to their beneficial physico-chemical properties, they are applicable in the cosmetic, pharmaceutical and food industry. The objective of the study was to investigate the effect of various co-surfactants on the formulations of o/w microemulsions containing 1-monoacylglycerols (1-MAG) with fatty acids of different chain length, namely capric (C10:0), lauric (C12:0) and myristic (C14:0) acids. Medium-chain length alcohols (ethanol, 1-propanol, 1-butanol, 1-pentanol) were used as co-surfactants, and Tween 80 as a surfactant. Phase behaviour of the emulsion systems was studied with the help of pseudo-ternary phase diagrams, which were then used to determine final composition of microemulsions. On the optimum formulations, the size of the microemulsion droplets was determined using photon correlation spectroscopy and their antibacterial properties against the most common pathogens were studied. The results indicated that the largest region of limited miscibility was observed for microemulsions with the co-surfactant pentanol. For systems wherein ethanol, butanol and propanol were used, the reduction of immiscibility area compared with pentanol was determined. Phase diagrams proved that the area of limited miscibility for the respective 1-MAG increased with increasing chain length of the used alcohol. Regarding size, the emulsions droplets were of about 12-24 nm and the best antibacterial properties were determined on 1-MAG C12:0 microemulsions irrespective of co-surfactant used. (en)
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| Title
| - Formulation and characterization of 1-monoacylglycerols-loaded microemulsions
- Formulation and characterization of 1-monoacylglycerols-loaded microemulsions (en)
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| skos:prefLabel
| - Formulation and characterization of 1-monoacylglycerols-loaded microemulsions
- Formulation and characterization of 1-monoacylglycerols-loaded microemulsions (en)
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| skos:notation
| - RIV/70883521:28610/14:43871699!RIV15-MSM-28610___
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| http://linked.open...avai/riv/aktivita
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| http://linked.open...avai/riv/aktivity
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| http://linked.open...vai/riv/dodaniDat
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| http://linked.open...aciTvurceVysledku
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| http://linked.open.../riv/druhVysledku
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| http://linked.open...iv/duvernostUdaju
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| http://linked.open...titaPredkladatele
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| http://linked.open...dnocenehoVysledku
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| http://linked.open...ai/riv/idVysledku
| - RIV/70883521:28610/14:43871699
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| http://linked.open...riv/jazykVysledku
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| http://linked.open.../riv/klicovaSlova
| - microemulsions, monoacylglycerols, antibacterial properties (en)
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| http://linked.open.../riv/klicoveSlovo
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| http://linked.open...ontrolniKodProRIV
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| http://linked.open...in/vavai/riv/obor
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| http://linked.open...ichTvurcuVysledku
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| http://linked.open...cetTvurcuVysledku
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| http://linked.open...UplatneniVysledku
| |
| http://linked.open...iv/tvurceVysledku
| - Buňková, Leona
- Kašpárková, Věra
- Mikulcová, Veronika
- Hauerlandová, Iva
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| http://localhost/t...ganizacniJednotka
| |
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