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| Description
| - Objective: The aim of the study is to compare estimated glomerular filtration rate (eGFR) from serum creatinine (eGFRcreatinine) and cystatine C (eGFRcystatin C) and to study the impact of these estimations on detection and staging of chronic kidney disease (CKD) in diabetic patients. Design: retrospective cross section design. Settings: Department of clinical biochemistry, Tomas Bata Hospital Inc., Zlín, Czech Republic. Materials and methods: The study population consisted of 565 consecutive diabetic patients from the outpatient diabetic clinic of Tomas Bata Hospital in Zlin in the Czech Republic. Serum creatinine and cystatin C were measured by newly standardized methods and eGFR was calculated according to Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equations, which were established in 2012. CKD is defined as GFR below 1.0 ml/s/1.73m2. Results: The mean eGFRcreatinine (1.443 ± 0.014) ml/s/1.73m2 was lower than eGFRcystatin C (1.512 ± 0.017) ml/s/1.73m 2, (p < 0.002). We found poor accordance to identify CKD. The discrepancy was found in 38 patients. Conclusion: Mean eGFRcystatin C was significantly higher than eGFRcreatinine. eGFR cystatin C gives higher values than eGFRcreatinine mainly at eGFR over 1.5 ml/s/1.73m2. Our results support the use of both eGFRcystatin C and eGFRcreatinine +cystatin C in patients with diabetes mellitus without albuminuria or another marker of kidney damage at GFR stages 2 and 3a according to eGFRcreatinine.
- Objective: The aim of the study is to compare estimated glomerular filtration rate (eGFR) from serum creatinine (eGFRcreatinine) and cystatine C (eGFRcystatin C) and to study the impact of these estimations on detection and staging of chronic kidney disease (CKD) in diabetic patients. Design: retrospective cross section design. Settings: Department of clinical biochemistry, Tomas Bata Hospital Inc., Zlín, Czech Republic. Materials and methods: The study population consisted of 565 consecutive diabetic patients from the outpatient diabetic clinic of Tomas Bata Hospital in Zlin in the Czech Republic. Serum creatinine and cystatin C were measured by newly standardized methods and eGFR was calculated according to Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equations, which were established in 2012. CKD is defined as GFR below 1.0 ml/s/1.73m2. Results: The mean eGFRcreatinine (1.443 ± 0.014) ml/s/1.73m2 was lower than eGFRcystatin C (1.512 ± 0.017) ml/s/1.73m 2, (p < 0.002). We found poor accordance to identify CKD. The discrepancy was found in 38 patients. Conclusion: Mean eGFRcystatin C was significantly higher than eGFRcreatinine. eGFR cystatin C gives higher values than eGFRcreatinine mainly at eGFR over 1.5 ml/s/1.73m2. Our results support the use of both eGFRcystatin C and eGFRcreatinine +cystatin C in patients with diabetes mellitus without albuminuria or another marker of kidney damage at GFR stages 2 and 3a according to eGFRcreatinine. (en)
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| Title
| - Estimated glomerular filtration rate in diabetic patients
- Estimated glomerular filtration rate in diabetic patients (en)
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| skos:prefLabel
| - Estimated glomerular filtration rate in diabetic patients
- Estimated glomerular filtration rate in diabetic patients (en)
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| skos:notation
| - RIV/70883521:28610/14:43871580!RIV15-MSM-28610___
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| http://linked.open...avai/riv/aktivita
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| http://linked.open...avai/riv/aktivity
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| http://linked.open...iv/cisloPeriodika
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| http://linked.open...vai/riv/dodaniDat
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| http://linked.open...aciTvurceVysledku
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| http://linked.open.../riv/druhVysledku
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| http://linked.open...iv/duvernostUdaju
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| http://linked.open...titaPredkladatele
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| http://linked.open...dnocenehoVysledku
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| http://linked.open...ai/riv/idVysledku
| - RIV/70883521:28610/14:43871580
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| http://linked.open...riv/jazykVysledku
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| http://linked.open.../riv/klicovaSlova
| - Glomerular filtration rate; Cystatin C; Creatinine; Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI); Chronic kidney disease (en)
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| http://linked.open.../riv/klicoveSlovo
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| http://linked.open...odStatuVydavatele
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| http://linked.open...ontrolniKodProRIV
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| http://linked.open...i/riv/nazevZdroje
| - Klinická Biochemie a Metabolismus
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| http://linked.open...in/vavai/riv/obor
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| http://linked.open...ichTvurcuVysledku
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| http://linked.open...cetTvurcuVysledku
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| http://linked.open...UplatneniVysledku
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| http://linked.open...v/svazekPeriodika
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| http://linked.open...iv/tvurceVysledku
| - Ponížil, Petr
- Šálek, Tomáš
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| issn
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| number of pages
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| http://localhost/t...ganizacniJednotka
| |
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