About: Development of metallcomplex amino acids synthons for the asymmetric preparation of alpha-amino acids by stereoselective introduction of a side chain

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About: Development of metallcomplex amino acids synthons for the asymmetric preparation of alpha-amino acids by stereoselective introduction of a side chain Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	In this communication the evaluation of eleven new metalocomplex alanine synthons bearing C2-symmetric benzyl groups with electron-donating and electron-withdrawing substituents is described. Alpha-Methylated glycine synthons (alanine complexes) were evaluated alongside alanine synthons in order to obtain a deeper understanding of the relationship between their structures and stereochemistry of monoalkylated products and to choose several candidates for their further tests for stereospecific preparation of 6-[18F]FDOPA. Glycine-derived analogues of the complexes 3-5 are the best candidates for the development of a 6-[18F]FDOPA preparation procedure. In the model epimerization reaction they demonstrated the best performance, much better compared to the previously described compound 2. Complexes 3, 5, and 8 are the best in asymmetric preparation of beta-13C monolabelled alpha-aminoisobutyric acid. The have to be tested in the preparation of alpha-methyl amino acids like 6-[18F]-alpha-methylDOPA and 2-[1 In this communication the evaluation of eleven new metalocomplex alanine synthons bearing C2-symmetric benzyl groups with electron-donating and electron-withdrawing substituents is described. Alpha-Methylated glycine synthons (alanine complexes) were evaluated alongside alanine synthons in order to obtain a deeper understanding of the relationship between their structures and stereochemistry of monoalkylated products and to choose several candidates for their further tests for stereospecific preparation of 6-[18F]FDOPA. Glycine-derived analogues of the complexes 3-5 are the best candidates for the development of a 6-[18F]FDOPA preparation procedure. In the model epimerization reaction they demonstrated the best performance, much better compared to the previously described compound 2. Complexes 3, 5, and 8 are the best in asymmetric preparation of beta-13C monolabelled alpha-aminoisobutyric acid. The have to be tested in the preparation of alpha-methyl amino acids like 6-[18F]-alpha-methylDOPA and 2-[1 (en)
Title	Development of metallcomplex amino acids synthons for the asymmetric preparation of alpha-amino acids by stereoselective introduction of a side chain Development of metallcomplex amino acids synthons for the asymmetric preparation of alpha-amino acids by stereoselective introduction of a side chain (en)
skos:prefLabel	Development of metallcomplex amino acids synthons for the asymmetric preparation of alpha-amino acids by stereoselective introduction of a side chain Development of metallcomplex amino acids synthons for the asymmetric preparation of alpha-amino acids by stereoselective introduction of a side chain (en)
skos:notation	RIV/70883521:28110/10:63510063!RIV11-MSM-28110___
http://linked.open...avai/riv/aktivita	V
http://linked.open...avai/riv/aktivity	V
http://linked.open...iv/cisloPeriodika	3
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Popkov, Alexandr
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Tomáše Bati ve Zlíně / Fakulta technologická
http://linked.open...dnocenehoVysledku	253970
http://linked.open...ai/riv/idVysledku	RIV/70883521:28110/10:63510063
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	aminoacids; 6-[18F]FDOPA; stereoselectivity; nickel; PET; Schiff bases (en)
http://linked.open.../riv/klicoveSlovo	PET aminoacids stereoselectivity nickel Schiff bases 6-[18F]FDOPA
http://linked.open...odStatuVydavatele	NL - Nizozemsko
http://linked.open...ontrolniKodProRIV	[DF350D203A15]
http://linked.open...i/riv/nazevZdroje	Journal of Radioanalytical Nuclear Chemistry
http://linked.open...in/vavai/riv/obor	CC
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	7 (xsd:int)
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	285
http://linked.open...iv/tvurceVysledku	Holčapek, M. Čermák, J. Jirásko, R. Langer, V. Popkov, Alexandr Hanusek, J. Nádvorník, M.
issn	0236-5731
number of pages	6 (xsd:int)
http://localhost/t...ganizacniJednotka	28110

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