About: Anticancer Activity of Lignan from the Aerial Parts of Saussurea salicifolia (L.) DC     Goto   Sponge   NotDistinct   Permalink

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  • Aerial parts of Saussurea salicifolia (L.) DC were studied for their lignan and flavonoids in solvent chloroform and n-butanol of ethanolic extract. Isolation and identification of phenolic compounds of the chloroform and n-butanol fractions were performed with Dionex HPLC-DAD system with water-methanol gradients in 4 different wave lengths (235 nm, 254 nm, 280 nm and 340 nm), using online UV and LC-MS as described previously. 9-OH-pinoresinol which is a lignan with anticancer activity was dominated in the chloroform fraction, whereas mainly flavonoid glycosides like quercetin-3-o-galactoside, apigenin-7-o-rhamnoside with anti-inflammatory effect were detected in the n-butanol fraction. Additionally, 9-OH-pinoresinol was also found in the n-butanol fraction. Anticancer tests were conducted in leukemia mouse lymphoma cells L5178Y at a concentration of 10 μg/ml of test compound. Crude ethanol extract of S. salicifolia reduced the growth of leukemia mouse lymphoma cells L5178Y to 23.8%.
  • Aerial parts of Saussurea salicifolia (L.) DC were studied for their lignan and flavonoids in solvent chloroform and n-butanol of ethanolic extract. Isolation and identification of phenolic compounds of the chloroform and n-butanol fractions were performed with Dionex HPLC-DAD system with water-methanol gradients in 4 different wave lengths (235 nm, 254 nm, 280 nm and 340 nm), using online UV and LC-MS as described previously. 9-OH-pinoresinol which is a lignan with anticancer activity was dominated in the chloroform fraction, whereas mainly flavonoid glycosides like quercetin-3-o-galactoside, apigenin-7-o-rhamnoside with anti-inflammatory effect were detected in the n-butanol fraction. Additionally, 9-OH-pinoresinol was also found in the n-butanol fraction. Anticancer tests were conducted in leukemia mouse lymphoma cells L5178Y at a concentration of 10 μg/ml of test compound. Crude ethanol extract of S. salicifolia reduced the growth of leukemia mouse lymphoma cells L5178Y to 23.8%. (en)
Title
  • Anticancer Activity of Lignan from the Aerial Parts of Saussurea salicifolia (L.) DC
  • Anticancer Activity of Lignan from the Aerial Parts of Saussurea salicifolia (L.) DC (en)
skos:prefLabel
  • Anticancer Activity of Lignan from the Aerial Parts of Saussurea salicifolia (L.) DC
  • Anticancer Activity of Lignan from the Aerial Parts of Saussurea salicifolia (L.) DC (en)
skos:notation
  • RIV/70883521:28110/09:63508767!RIV10-MSM-28110___
http://linked.open...avai/riv/aktivita
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  • V
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  • SI
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  • 303452
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  • RIV/70883521:28110/09:63508767
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  • flavonoids; Saussurea salicifolia; anticancer activity; Dionex HPLC-DAD system (en)
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  • CZ - Česká republika
http://linked.open...ontrolniKodProRIV
  • [86CB0D9A9ED4]
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  • Czech Journal of Food Sciences
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  • 27
http://linked.open...iv/tvurceVysledku
  • Valášek, Pavel
  • Hoza, Ignác
  • Škrovánková, Soňa
  • Banzragch, D.
  • Chunsrijmytay, G.
  • Tsevegsuren, Nanzad
issn
  • 1212-1800
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http://localhost/t...ganizacniJednotka
  • 28110
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