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rdf:type
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Description
| - The most important mucopolysaccharide, hyaluronic acid (HA), is a linear carbohydrate polymer. Its disaccharide monomeric unit is built up of N-acetyl D-glucosamine and D-glucuronic acid interconnected via b (1#4) and b (1#4) interglycosidic bonds. In aqueous solutions HA forms rigid domains built up from about 10 - 20 monomer units strongly bound by the systém of intra- and inter- molecular hydrogen bonds, thus producing its characteristics of secondary a tertiary configurations. These structures couldbe strongly influenced by insertion on n-alkyl spacers as a branch into this systems. For this reason, five n-alkyl derivatives on the CH2-OH groups of hyaluronic acid, from n-C6- to n-C16- were prepared. The following properties of these products are r eviewed: Kinetic parameters of dissolution, study of enzymatic degradation, thermal analysis and measurements of its electric properties.
- The most important mucopolysaccharide, hyaluronic acid (HA), is a linear carbohydrate polymer. Its disaccharide monomeric unit is built up of N-acetyl D-glucosamine and D-glucuronic acid interconnected via b (1#4) and b (1#4) interglycosidic bonds. In aqueous solutions HA forms rigid domains built up from about 10 - 20 monomer units strongly bound by the systém of intra- and inter- molecular hydrogen bonds, thus producing its characteristics of secondary a tertiary configurations. These structures couldbe strongly influenced by insertion on n-alkyl spacers as a branch into this systems. For this reason, five n-alkyl derivatives on the CH2-OH groups of hyaluronic acid, from n-C6- to n-C16- were prepared. The following properties of these products are r eviewed: Kinetic parameters of dissolution, study of enzymatic degradation, thermal analysis and measurements of its electric properties. (en)
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Title
| - Study of chemical modification of hyaluronic acid
- Study of chemical modification of hyaluronic acid (en)
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skos:prefLabel
| - Study of chemical modification of hyaluronic acid
- Study of chemical modification of hyaluronic acid (en)
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skos:notation
| - RIV/70883521:28110/01:63500362!RIV/2002/MSM/281102/N
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http://linked.open.../vavai/riv/strany
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http://linked.open...avai/riv/aktivita
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http://linked.open...avai/riv/aktivity
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http://linked.open...vai/riv/dodaniDat
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http://linked.open...aciTvurceVysledku
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http://linked.open.../riv/druhVysledku
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http://linked.open...iv/duvernostUdaju
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http://linked.open...titaPredkladatele
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http://linked.open...dnocenehoVysledku
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http://linked.open...ai/riv/idVysledku
| - RIV/70883521:28110/01:63500362
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http://linked.open...riv/jazykVysledku
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http://linked.open.../riv/klicovaSlova
| - hyaluronic acid, chemical modification, polysaccharides (en)
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http://linked.open.../riv/klicoveSlovo
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http://linked.open...ontrolniKodProRIV
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http://linked.open...v/mistoKonaniAkce
| - Košice, Slovenská Republika
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http://linked.open...i/riv/mistoVydani
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http://linked.open...i/riv/nazevZdroje
| - Structure and Stability of Biomacromolecules SSB'01
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http://linked.open...in/vavai/riv/obor
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http://linked.open...ichTvurcuVysledku
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http://linked.open...cetTvurcuVysledku
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http://linked.open...ocetUcastnikuAkce
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http://linked.open...nichUcastnikuAkce
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http://linked.open...UplatneniVysledku
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http://linked.open...iv/tvurceVysledku
| - Lapčík, Lubomír
- Benešová, K.
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http://linked.open...vavai/riv/typAkce
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http://linked.open.../riv/zahajeniAkce
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http://linked.open...n/vavai/riv/zamer
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number of pages
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http://purl.org/ne...btex#hasPublisher
| - Slovenská akadémia vied; Univerzita Pavla Jozefa Šafárika v Košiciach
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http://localhost/t...ganizacniJednotka
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