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| rdf:type
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| Description
| - The scope of use fullerenes and their derivatives, thank to their material and bonding properties, is increasing, including their application in biological system. The possibility of their use as substances affecting to the effect of ioninising radiationwas examined experimentally in vivo individual of Danio rerio in jeveline age )2,5 months) without differentiated sex and in vitro in tissue cultures in primoculture of guinea pig kidney cells and in melanoma cells B16-F10, parallelto the toxicty test. in order to achieve the accessibility of fullerenes for living organisms the reaction of C60 fullerene with peracetigacid and followed by hydrolysis of oxo-fullerene prapared in water-soluble fullerene derivative characterised by its Fourrier transformation infra-red spectrum (FTIR), and in its solution at a concentration of 147mg/L individuals of the jevenile form of Danio rerio can survive for a long time without sings of toxic effect. A radioprotective effect was showen in fish after their five day stay in its soultion.The period of survival increaces after radiation by 10 to 70 Gy doses and up 70%, and the LD50 value for various periods of survival roughly doubles. The effect showen is preventive and is probably associated with the ability of fullerenes to be able to eliminate free radicals and oxidants appering by water radiolysis. Unlike fish, the prepared derived fullerene solution for tissue culture in vitro are toxic in unit contrencations of upto tens of mg/L, whereas free cells are roughly 5 times more sensitive.No protective effectwas observed in tissue cultures exposed briefly before radiation to the effect of the fullerene derivate solution. This may be consequence of brief contact with fulleren nanoparticles before radiation when there was no time for them to penetrate the cells.
- The scope of use fullerenes and their derivatives, thank to their material and bonding properties, is increasing, including their application in biological system. The possibility of their use as substances affecting to the effect of ioninising radiationwas examined experimentally in vivo individual of Danio rerio in jeveline age )2,5 months) without differentiated sex and in vitro in tissue cultures in primoculture of guinea pig kidney cells and in melanoma cells B16-F10, parallelto the toxicty test. in order to achieve the accessibility of fullerenes for living organisms the reaction of C60 fullerene with peracetigacid and followed by hydrolysis of oxo-fullerene prapared in water-soluble fullerene derivative characterised by its Fourrier transformation infra-red spectrum (FTIR), and in its solution at a concentration of 147mg/L individuals of the jevenile form of Danio rerio can survive for a long time without sings of toxic effect. A radioprotective effect was showen in fish after their five day stay in its soultion.The period of survival increaces after radiation by 10 to 70 Gy doses and up 70%, and the LD50 value for various periods of survival roughly doubles. The effect showen is preventive and is probably associated with the ability of fullerenes to be able to eliminate free radicals and oxidants appering by water radiolysis. Unlike fish, the prepared derived fullerene solution for tissue culture in vitro are toxic in unit contrencations of upto tens of mg/L, whereas free cells are roughly 5 times more sensitive.No protective effectwas observed in tissue cultures exposed briefly before radiation to the effect of the fullerene derivate solution. This may be consequence of brief contact with fulleren nanoparticles before radiation when there was no time for them to penetrate the cells. (en)
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| Title
| - C60 Fullerene Derivative: Radioprotectiva Properties and a Toxicity Test in Vivo and in Vitro
- C60 Fullerene Derivative: Radioprotectiva Properties and a Toxicity Test in Vivo and in Vitro (en)
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| skos:prefLabel
| - C60 Fullerene Derivative: Radioprotectiva Properties and a Toxicity Test in Vivo and in Vitro
- C60 Fullerene Derivative: Radioprotectiva Properties and a Toxicity Test in Vivo and in Vitro (en)
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| skos:notation
| - RIV/70565813:_____/12:#0000289!RIV13-MV0-70565813
|
| http://linked.open...avai/riv/aktivita
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| http://linked.open...avai/riv/aktivity
| |
| http://linked.open...iv/cisloPeriodika
| |
| http://linked.open...vai/riv/dodaniDat
| |
| http://linked.open...aciTvurceVysledku
| |
| http://linked.open.../riv/druhVysledku
| |
| http://linked.open...iv/duvernostUdaju
| |
| http://linked.open...titaPredkladatele
| |
| http://linked.open...dnocenehoVysledku
| |
| http://linked.open...ai/riv/idVysledku
| - RIV/70565813:_____/12:#0000289
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| http://linked.open...riv/jazykVysledku
| |
| http://linked.open.../riv/klicovaSlova
| - C60 derivative, radioprotectivity, toxicity, Danio rerio, in vivo, in vitro (en)
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| http://linked.open.../riv/klicoveSlovo
| |
| http://linked.open...odStatuVydavatele
| - US - Spojené státy americké
|
| http://linked.open...ontrolniKodProRIV
| |
| http://linked.open...i/riv/nazevZdroje
| - Journal of Materials Science and Engineerin A
|
| http://linked.open...in/vavai/riv/obor
| |
| http://linked.open...ichTvurcuVysledku
| |
| http://linked.open...cetTvurcuVysledku
| |
| http://linked.open...vavai/riv/projekt
| |
| http://linked.open...UplatneniVysledku
| |
| http://linked.open...v/svazekPeriodika
| |
| http://linked.open...iv/tvurceVysledku
| - Danihelka, Pavel
- Klouda, Karel
- Zeman, Karel
- Zemanová, Eva
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| issn
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| number of pages
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