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| Description
| - The study investigated the contribution of abnormal sympathetic influences to the changes of ventricular repolarization pattern in rabbits with short-term diabetes. The experiments were performed in anaesthetized 11 alloxan-induced (4-5 weeks) diabetic and 13 healthy rabbits. Unipolar electrograms were recorded from 64 ventricular epicardial leads prior to and after the injection of beta1-blocker esmolol (0.5 mg/kg, i.v.). Activation times (dV/dt min during QRS), end of repolarization times (dV/dt max during ST-T) and their differences (activationrecovery intervals) were determined. In diabetic rabbits, activation-recovery intervals were longer in the left ventricular apex than in its base, on the right ventricular free wall than on the left ventricular free wall, and on the anterior surface than on the posterior surface (P<0.05). Injection of esmolol in control group resulted in the development of the significant apicobasal difference in repolarization durations (P<0.05). In the diabetic group, esmolol abrogated all the ventricular repolarization gradients by the preferential prolongation of the initially shorter repolarization durations. Thus, the 4-5 weeks diabetes-induced left ventricular apicobasal, interventricular and anteroposterior repolarization duration gradients at least in part could be ascribed to the sympathetic dysfunction as being abolished by the beta1-adrenergic blockade.
- The study investigated the contribution of abnormal sympathetic influences to the changes of ventricular repolarization pattern in rabbits with short-term diabetes. The experiments were performed in anaesthetized 11 alloxan-induced (4-5 weeks) diabetic and 13 healthy rabbits. Unipolar electrograms were recorded from 64 ventricular epicardial leads prior to and after the injection of beta1-blocker esmolol (0.5 mg/kg, i.v.). Activation times (dV/dt min during QRS), end of repolarization times (dV/dt max during ST-T) and their differences (activationrecovery intervals) were determined. In diabetic rabbits, activation-recovery intervals were longer in the left ventricular apex than in its base, on the right ventricular free wall than on the left ventricular free wall, and on the anterior surface than on the posterior surface (P<0.05). Injection of esmolol in control group resulted in the development of the significant apicobasal difference in repolarization durations (P<0.05). In the diabetic group, esmolol abrogated all the ventricular repolarization gradients by the preferential prolongation of the initially shorter repolarization durations. Thus, the 4-5 weeks diabetes-induced left ventricular apicobasal, interventricular and anteroposterior repolarization duration gradients at least in part could be ascribed to the sympathetic dysfunction as being abolished by the beta1-adrenergic blockade. (en)
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| Title
| - Esmolol abolishes repolarization gradients in diabetic rabbit hearts
- Esmolol abolishes repolarization gradients in diabetic rabbit hearts (en)
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| skos:prefLabel
| - Esmolol abolishes repolarization gradients in diabetic rabbit hearts
- Esmolol abolishes repolarization gradients in diabetic rabbit hearts (en)
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| skos:notation
| - RIV/68407700:21460/14:00219802!RIV15-MSM-21460___
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| http://linked.open...avai/riv/aktivita
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| http://linked.open...avai/riv/aktivity
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| http://linked.open...iv/cisloPeriodika
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| http://linked.open...vai/riv/dodaniDat
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| http://linked.open...aciTvurceVysledku
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| http://linked.open.../riv/druhVysledku
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| http://linked.open...iv/duvernostUdaju
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| http://linked.open...titaPredkladatele
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| http://linked.open...dnocenehoVysledku
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| http://linked.open...ai/riv/idVysledku
| - RIV/68407700:21460/14:00219802
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| http://linked.open...riv/jazykVysledku
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| http://linked.open.../riv/klicovaSlova
| - activation-recovery intervals; cardiac autonomic neuropathy; diabetes mellitus; rabbits; repolarization (en)
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| http://linked.open.../riv/klicoveSlovo
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| http://linked.open...odStatuVydavatele
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| http://linked.open...ontrolniKodProRIV
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| http://linked.open...i/riv/nazevZdroje
| - Experimental & Clinical Cardiology
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| http://linked.open...in/vavai/riv/obor
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| http://linked.open...ichTvurcuVysledku
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| http://linked.open...cetTvurcuVysledku
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| http://linked.open...UplatneniVysledku
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| http://linked.open...v/svazekPeriodika
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| http://linked.open...iv/tvurceVysledku
| - Sedova, Ksenia
- Shmakov, D.
- Azarov, J.
- Danilova, I.
- Medvedeva, S.
- Ovechkin, A.
- Shumikhin, K.
- Vaykshnorayte, M.
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| issn
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| number of pages
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| http://localhost/t...ganizacniJednotka
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