About: The Effect of Neural Noise on Spike Time Precision in a Detailed CA3 Neuron Model

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Experimental and computational studies emphasize the role of the millisecond precision of neuronal spike times as an important coding mechanism for transmitting and representing information in the central nervous system. We investigate the spike time precision of a multicompartmental pyramidal neuron model of the CA3 region of the hippocampus under the influence of various sources of neuronal noise. We describe differences in the contribution to noise originating from voltage-gated ion channels, synaptic vesicle release, and vesicle quantal size. We analyze the effect of interspike intervals and the voltage course preceding the firing of spikes on the spike-timing jitter. The main finding of this study is the ranking of different noise sources according to their contribution to spike time precision. The most influential is synaptic vesicle release noise, causing the spike jitter to vary from 1ms to 7 ms of a mean value 2.5 ms. Of second importance was the noise incurred by vesicle quantal size variation causing the spike time jitter to vary from 0.03 ms to 0.6 ms. Least influential was the voltage-gated channel noise generating spike jitter from 0.02 ms to 0.15 ms. Experimental and computational studies emphasize the role of the millisecond precision of neuronal spike times as an important coding mechanism for transmitting and representing information in the central nervous system. We investigate the spike time precision of a multicompartmental pyramidal neuron model of the CA3 region of the hippocampus under the influence of various sources of neuronal noise. We describe differences in the contribution to noise originating from voltage-gated ion channels, synaptic vesicle release, and vesicle quantal size. We analyze the effect of interspike intervals and the voltage course preceding the firing of spikes on the spike-timing jitter. The main finding of this study is the ranking of different noise sources according to their contribution to spike time precision. The most influential is synaptic vesicle release noise, causing the spike jitter to vary from 1ms to 7 ms of a mean value 2.5 ms. Of second importance was the noise incurred by vesicle quantal size variation causing the spike time jitter to vary from 0.03 ms to 0.6 ms. Least influential was the voltage-gated channel noise generating spike jitter from 0.02 ms to 0.15 ms. (en)
Title	The Effect of Neural Noise on Spike Time Precision in a Detailed CA3 Neuron Model The Effect of Neural Noise on Spike Time Precision in a Detailed CA3 Neuron Model (en)
skos:prefLabel	The Effect of Neural Noise on Spike Time Precision in a Detailed CA3 Neuron Model The Effect of Neural Noise on Spike Time Precision in a Detailed CA3 Neuron Model (en)
skos:notation	RIV/68407700:21460/12:00201975!RIV13-MSM-21460___
http://linked.open...avai/riv/aktivita	I P Z
http://linked.open...avai/riv/aktivity	I, P(FR-TI3/869), P(GP305/05/P198), Z(MSM0021620806)
http://linked.open...iv/cisloPeriodika	Leden
http://linked.open...vai/riv/dodaniDat	2013
http://linked.open...aciTvurceVysledku	Maršálek, Petr
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	České vysoké učení technické v Praze / Fakulta biomedicínského inženýrství
http://linked.open...dnocenehoVysledku	133168
http://linked.open...ai/riv/idVysledku	RIV/68407700:21460/12:00201975
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	NEOCORTICAL PYRAMIDAL NEURONS; RAT HIPPOCAMPAL-NEURONS; RETINAL GANGLION-CELLS; TIMING PRECISION; TEMPORAL PRECISION; SYNAPTIC-TRANSMISSION; POTASSIUM CHANNELS; CORTICAL-NEURONS; IN-VITRO; AREA CA1 (en)
http://linked.open.../riv/klicoveSlovo	IN-VITRO AREA CA1 CORTICAL-NEURONS NEOCORTICAL PYRAMIDAL NEURONS POTASSIUM CHANNELS RAT HIPPOCAMPAL-NEURONS RETINAL GANGLION-CELLS SYNAPTIC-TRANSMISSION TEMPORAL PRECISION TIMING PRECISION
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[69ACB29A69ED]
http://linked.open...i/riv/nazevZdroje	COMPUTATIONAL AND MATHEMATICAL METHODS IN MEDICINE
http://linked.open...in/vavai/riv/obor	JD
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...vavai/riv/projekt	Virtual patient - Simulator for medical education Influence of passive and active properties of neuronal membrane and its 3-D structure on the transmission and processing of information in neuron
http://linked.open...UplatneniVysledku	2012
http://linked.open...v/svazekPeriodika	2012
http://linked.open...iv/tvurceVysledku	Maršálek, Petr Kuriščák, E. Wünsch, Z. Štroffek, J.
http://linked.open...ain/vavai/riv/wos	000307564100001
http://linked.open...n/vavai/riv/zamer	Molekulární biologie a patologie buňky za normy a u vybraných klinicky závažných patologických procesů
issn	1748-670X
number of pages	16 (xsd:int)
http://bibframe.org/vocab/doi	10.1155/2012/595398
http://localhost/t...ganizacniJednotka	21460

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