| Attributes | Values |
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| rdf:type
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| Description
| - The paper is aimed to overview the published papers for analysis of the cancer treatment by restoration of normal physiological processes, in particular electromagnetic activity and apoptotic function of glycolytic phenotype cancer cells. Achievement of this target is based on estimation of the treatment based on bringing back normal mitochondrial function through inhibition of molecules (kinases) blocking the pyruvate pathway using dichloroacetate (DCA) or drugs with similar properties. This method is supported by considerable in vitro and in vivo experience by DCA treatment even in humans. Opening pyruvate pathway restores the proton space charge layer, the strong static electric field around mitochondria, ordering of water, and induction of strong non-linearity of microtubule electrically polar oscillations. Normal level of excitation of oscillations dependent on energy liberated from mitochondria and low damping keeps running physical processes regulated by electromagnetic field. DCA may act on a wide spectrum of cancers. Cancer cells might be brought back to a normal healthy state or be subject to apoptosis by DCA or a similar drug treatment. Clinical trials should test this method, verify the results, determine effectiveness, and assess adjuvant treatment methods. Experience with DCA would accumulate experimental data for development of novel drugs for cancer treatment through restoring the mitochondrial function.
- The paper is aimed to overview the published papers for analysis of the cancer treatment by restoration of normal physiological processes, in particular electromagnetic activity and apoptotic function of glycolytic phenotype cancer cells. Achievement of this target is based on estimation of the treatment based on bringing back normal mitochondrial function through inhibition of molecules (kinases) blocking the pyruvate pathway using dichloroacetate (DCA) or drugs with similar properties. This method is supported by considerable in vitro and in vivo experience by DCA treatment even in humans. Opening pyruvate pathway restores the proton space charge layer, the strong static electric field around mitochondria, ordering of water, and induction of strong non-linearity of microtubule electrically polar oscillations. Normal level of excitation of oscillations dependent on energy liberated from mitochondria and low damping keeps running physical processes regulated by electromagnetic field. DCA may act on a wide spectrum of cancers. Cancer cells might be brought back to a normal healthy state or be subject to apoptosis by DCA or a similar drug treatment. Clinical trials should test this method, verify the results, determine effectiveness, and assess adjuvant treatment methods. Experience with DCA would accumulate experimental data for development of novel drugs for cancer treatment through restoring the mitochondrial function. (en)
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| Title
| - Targeting mitochondria for cancer treatment
- Targeting mitochondria for cancer treatment (en)
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| skos:prefLabel
| - Targeting mitochondria for cancer treatment
- Targeting mitochondria for cancer treatment (en)
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| skos:notation
| - RIV/68407700:21460/12:00195443!RIV13-MSM-21460___
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| http://linked.open...avai/riv/aktivita
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| http://linked.open...avai/riv/aktivity
| - I, P(GAP102/10/0120), P(GAP102/11/0649), P(GD102/08/H008), S
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| http://linked.open...iv/cisloPeriodika
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| http://linked.open...vai/riv/dodaniDat
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| http://linked.open...aciTvurceVysledku
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| http://linked.open.../riv/druhVysledku
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| http://linked.open...iv/duvernostUdaju
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| http://linked.open...titaPredkladatele
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| http://linked.open...dnocenehoVysledku
| |
| http://linked.open...ai/riv/idVysledku
| - RIV/68407700:21460/12:00195443
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| http://linked.open...riv/jazykVysledku
| |
| http://linked.open.../riv/klicovaSlova
| - Cancer glycolytic phenotype; mitochondrial dysfunction; dichloroacetate (DCA); physical processes in cells; apoptosis (en)
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| http://linked.open.../riv/klicoveSlovo
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| http://linked.open...odStatuVydavatele
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| http://linked.open...ontrolniKodProRIV
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| http://linked.open...i/riv/nazevZdroje
| - EUROPEAN JOURNAL OF ONCOLOGY
|
| http://linked.open...in/vavai/riv/obor
| |
| http://linked.open...ichTvurcuVysledku
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| http://linked.open...cetTvurcuVysledku
| |
| http://linked.open...vavai/riv/projekt
| |
| http://linked.open...UplatneniVysledku
| |
| http://linked.open...v/svazekPeriodika
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| http://linked.open...iv/tvurceVysledku
| - Cifra, M.
- Kučera, Ondřej
- Pokorný, J.
- Vrba, Jan
- Jandova, A.
- Kobilkova, J.
- Srobar, F.
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| http://linked.open...ain/vavai/riv/wos
| |
| issn
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| number of pages
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| http://localhost/t...ganizacniJednotka
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