About: Optical Detection of Charged Biomolecules: Towards Novel Drug Delivery Systems

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://ctn.cvut.cz/ap/index.php?year=2011&idissue=75
Description	This paper presents work done on developing optically-traceable intracellular nanodiamond sensors, where the photoluminescence can be changed by a biomolecular attachment/delivery event. Their high biocompatibility, small size and stable luminescence from their color centers make nanodiamond (ND) particles an attractive alternative to molecular dyes for drug-delivery and cell-imaging applications. In our work, we study how surface modification of ND can change the color of ND luminescence (PL). This method can be used as a novel detection tool for remote monitoring of chemical processes in biological systems. Recently, we showed that PL can be driven by atomic functionalization, leading to a change in the color of ND luminescence from red (oxidized ND) to orange (hydrogenated ND). In this work, we show how PL of ND changes similarly when interacting with positively and negatively charged molecules. The effect is demonstrated on fluorinated ND, This paper presents work done on developing optically-traceable intracellular nanodiamond sensors, where the photoluminescence can be changed by a biomolecular attachment/delivery event. Their high biocompatibility, small size and stable luminescence from their color centers make nanodiamond (ND) particles an attractive alternative to molecular dyes for drug-delivery and cell-imaging applications. In our work, we study how surface modification of ND can change the color of ND luminescence (PL). This method can be used as a novel detection tool for remote monitoring of chemical processes in biological systems. Recently, we showed that PL can be driven by atomic functionalization, leading to a change in the color of ND luminescence from red (oxidized ND) to orange (hydrogenated ND). In this work, we show how PL of ND changes similarly when interacting with positively and negatively charged molecules. The effect is demonstrated on fluorinated ND, (en)
Title	Optical Detection of Charged Biomolecules: Towards Novel Drug Delivery Systems Optical Detection of Charged Biomolecules: Towards Novel Drug Delivery Systems (en)
skos:prefLabel	Optical Detection of Charged Biomolecules: Towards Novel Drug Delivery Systems Optical Detection of Charged Biomolecules: Towards Novel Drug Delivery Systems (en)
skos:notation	RIV/68407700:21460/11:00183547!RIV12-MSM-21460___
http://linked.open...avai/riv/aktivita	P S Z
http://linked.open...avai/riv/aktivity	P(LD11078), S, Z(MSM6840770012)
http://linked.open...iv/cisloPeriodika	5
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Petráková, Vladimíra
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	České vysoké učení technické v Praze / Fakulta biomedicínského inženýrství
http://linked.open...dnocenehoVysledku	218534
http://linked.open...ai/riv/idVysledku	RIV/68407700:21460/11:00183547
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	nanodiamond; drug delivery; nitrogen-vacancy center; luminescence properties; charged molecules (en)
http://linked.open.../riv/klicoveSlovo	nanodiamond luminescence properties charged molecules nitrogen-vacancy center drug delivery
http://linked.open...odStatuVydavatele	CZ - Česká republika
http://linked.open...ontrolniKodProRIV	[E20527F77C7E]
http://linked.open...i/riv/nazevZdroje	Acta Polytechnica
http://linked.open...in/vavai/riv/obor	BO
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	1 (xsd:int)
http://linked.open...vavai/riv/projekt	Real time nanophotonic imaging in cells using nanodiamond particles
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	2011
http://linked.open...iv/tvurceVysledku	Petráková, Vladimíra
http://linked.open...n/vavai/riv/zamer	Transdisciplinární výzkum v oblasti biomedicínského inženýrství II
issn	1210-2709
number of pages	5 (xsd:int)
http://localhost/t...ganizacniJednotka	21460

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