About: Remodelling of living bone induced by dynamic loading and drug delivery-Numerical modelling and clinical treatment     Goto   Sponge   NotDistinct   Permalink

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  • The biomechanical remodelling process is well formulated for bones and is divided into three stages: (1) bone resorption based on the osteoclast activity, (2) bone deposition based on the osteoblast activity and (3) bone growth control established on RANK/RANKL/OPG pathway-RANKL/OPG balance. The main driving force of remodelling process is a dynamic loading (cyclic compression and expansion, e.g. walking or running), which strongly influences the rate of chemical reactions. The evolution from the omogeneous density distribution to the corticalis and cancellous bone formation is shown. An inevitable influence of a dynamic mechanical loading and osteoprotegerin (OPG) concentration is demonstrated.
  • The biomechanical remodelling process is well formulated for bones and is divided into three stages: (1) bone resorption based on the osteoclast activity, (2) bone deposition based on the osteoblast activity and (3) bone growth control established on RANK/RANKL/OPG pathway-RANKL/OPG balance. The main driving force of remodelling process is a dynamic loading (cyclic compression and expansion, e.g. walking or running), which strongly influences the rate of chemical reactions. The evolution from the omogeneous density distribution to the corticalis and cancellous bone formation is shown. An inevitable influence of a dynamic mechanical loading and osteoprotegerin (OPG) concentration is demonstrated. (en)
Title
  • Remodelling of living bone induced by dynamic loading and drug delivery-Numerical modelling and clinical treatment
  • Remodelling of living bone induced by dynamic loading and drug delivery-Numerical modelling and clinical treatment (en)
skos:prefLabel
  • Remodelling of living bone induced by dynamic loading and drug delivery-Numerical modelling and clinical treatment
  • Remodelling of living bone induced by dynamic loading and drug delivery-Numerical modelling and clinical treatment (en)
skos:notation
  • RIV/68407700:21340/10:00158919!RIV11-GA0-21340___
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • P(GA106/03/1073), P(GA106/08/0557), Z(AV0Z20760514)
http://linked.open...iv/cisloPeriodika
  • 6
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 284751
http://linked.open...ai/riv/idVysledku
  • RIV/68407700:21340/10:00158919
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • Bone remodelling; Chemical kinetics; Biochemical model; Numerical simulation (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • NL - Nizozemsko
http://linked.open...ontrolniKodProRIV
  • [21FF327088B6]
http://linked.open...i/riv/nazevZdroje
  • Mathematics and Computers in Simulation
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...vavai/riv/projekt
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 80
http://linked.open...iv/tvurceVysledku
  • Chlup, Hynek
  • Maršík, František
  • Klika, Václav
http://linked.open...ain/vavai/riv/wos
  • 000276380400024
http://linked.open...n/vavai/riv/zamer
issn
  • 0378-4754
number of pages
http://localhost/t...ganizacniJednotka
  • 21340
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