About: Searching for Important Amino Acids in DNA-binding Proteins for Histogram Methods

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://www.cs.gsu.edu/isbra11/wp-content/uploads/2010/07/ISBRA2011ShortAbstracts.pdf
Description	We develop a method capable to identify important amino acids for histogram-based methods predicting DNA-binding propensity. This method can be used both for prediction from sequence information Tube Histograms) and prediction from structural information (Ball Histograms). We validate our method in prediction experiments using only proteins' primary structure, achieving favourable accuracies. Moreover, the histogram-based methods equipped with this new searching method also provide interpretable features involving distributions of amino acids. We develop a method capable to identify important amino acids for histogram-based methods predicting DNA-binding propensity. This method can be used both for prediction from sequence information Tube Histograms) and prediction from structural information (Ball Histograms). We validate our method in prediction experiments using only proteins' primary structure, achieving favourable accuracies. Moreover, the histogram-based methods equipped with this new searching method also provide interpretable features involving distributions of amino acids. (en)
Title	Searching for Important Amino Acids in DNA-binding Proteins for Histogram Methods Searching for Important Amino Acids in DNA-binding Proteins for Histogram Methods (en)
skos:prefLabel	Searching for Important Amino Acids in DNA-binding Proteins for Histogram Methods Searching for Important Amino Acids in DNA-binding Proteins for Histogram Methods (en)
skos:notation	RIV/68407700:21230/11:00181845!RIV12-MSM-21230___
http://linked.open...avai/riv/aktivita	P S
http://linked.open...avai/riv/aktivity	P(ME10047), S
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Kuželka, Ondřej Železný, Filip Szabóová, Andrea
http://linked.open.../riv/druhVysledku	O - Ostatní výsledky nezařaditelné do žádného z výše uvedených druhů výsledku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	České vysoké učení technické v Praze / Fakulta elektrotechnická
http://linked.open...dnocenehoVysledku	228469
http://linked.open...ai/riv/idVysledku	RIV/68407700:21230/11:00181845
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Feature construction; Proteomics; DNA-binding proteins (en)
http://linked.open.../riv/klicoveSlovo	DNA-binding proteins Feature construction Proteomics
http://linked.open...ontrolniKodProRIV	[75B80968D3CD]
http://linked.open...in/vavai/riv/obor	JC
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...vavai/riv/projekt	Predictive Data Modeling for Effective Gene Therapy and Bone Marrow Transplantation
http://linked.open...UplatneniVysledku	2011
http://linked.open...iv/tvurceVysledku	Kuželka, Ondřej Szabóová, Andrea Tolar, J. Železný, Filip
http://localhost/t...ganizacniJednotka	21230

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