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  • Dimension reduction is the process of reducing the number of variables under consideration. In genomic classification it is widely applied because the high dimensionality of gene expression data proved to decrease accuracy and comprehensibility of genomic classifiers. Simultaneously, contemporary genomics offers an opportunity to reach beyond the routine application of purely statistical dimension reduction techniques. Availability of a great variability of knowledge on gene roles, functions and gene-gene interactions allows to benefit from knowledge-based approaches to dimension reduction. We extend our previous work, where a priori knowledge-based feature extraction method was introduced. The method called knowledge gene (KG) employs the gene keywords affinity to define a gene similarity measure.
  • Dimension reduction is the process of reducing the number of variables under consideration. In genomic classification it is widely applied because the high dimensionality of gene expression data proved to decrease accuracy and comprehensibility of genomic classifiers. Simultaneously, contemporary genomics offers an opportunity to reach beyond the routine application of purely statistical dimension reduction techniques. Availability of a great variability of knowledge on gene roles, functions and gene-gene interactions allows to benefit from knowledge-based approaches to dimension reduction. We extend our previous work, where a priori knowledge-based feature extraction method was introduced. The method called knowledge gene (KG) employs the gene keywords affinity to define a gene similarity measure. (en)
Title
  • Knowledge Gene: A Novel Feature Extraction Method in Genomics
  • Knowledge Gene: A Novel Feature Extraction Method in Genomics (en)
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  • Knowledge Gene: A Novel Feature Extraction Method in Genomics
  • Knowledge Gene: A Novel Feature Extraction Method in Genomics (en)
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  • RIV/68407700:21230/10:00176119!RIV11-MSM-21230___
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  • 266555
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  • RIV/68407700:21230/10:00176119
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  • feature extraction; background knowledge; gene expression; classification; gene annotation (en)
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  • [F792DAF47146]
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  • Praha
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  • Praha
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  • POSTER 2010 - Proceedings of the 14th International Conference on Electrical Engineering
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  • Krejník, Miloš
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  • České vysoké učení technické v Praze. Fakulta elektrotechnická
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  • 978-80-01-04544-2
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  • 21230
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