About: Epileptic high-frequency network activity in a model of non-lesional temporal lobe epilepsy

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About: Epileptic high-frequency network activity in a model of non-lesional temporal lobe epilepsy Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	High-frequency cortical activity, particularly in the 250-600 Hz (fast ripple) band, has been implicated in playing a crucial role in epileptogenesis and seizure generation. Fast ripples are highly specific for the seizure initiation zone. However, evidence for the association of fast ripples with epileptic foci depends on animal models and human cases with substantial lesions in the form of hippocampal sclerosis, which suggests that neuronal loss may be required for fast ripples. In the present work, we tested whether cell loss is a necessary prerequisite for the generation of fast ripples, using a non-lesional model of temporal lobe epilepsy that lacks hippocampal sclerosis. High-frequency cortical activity, particularly in the 250-600 Hz (fast ripple) band, has been implicated in playing a crucial role in epileptogenesis and seizure generation. Fast ripples are highly specific for the seizure initiation zone. However, evidence for the association of fast ripples with epileptic foci depends on animal models and human cases with substantial lesions in the form of hippocampal sclerosis, which suggests that neuronal loss may be required for fast ripples. In the present work, we tested whether cell loss is a necessary prerequisite for the generation of fast ripples, using a non-lesional model of temporal lobe epilepsy that lacks hippocampal sclerosis. (en)
Title	Epileptic high-frequency network activity in a model of non-lesional temporal lobe epilepsy Epileptic high-frequency network activity in a model of non-lesional temporal lobe epilepsy (en)
skos:prefLabel	Epileptic high-frequency network activity in a model of non-lesional temporal lobe epilepsy Epileptic high-frequency network activity in a model of non-lesional temporal lobe epilepsy (en)
skos:notation	RIV/68407700:21230/10:00167945!RIV11-MSM-21230___
http://linked.open...avai/riv/aktivita	S Z
http://linked.open...avai/riv/aktivity	S, Z(MSM6840770012)
http://linked.open...iv/cisloPeriodika	5
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Čmejla, Roman
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	České vysoké učení technické v Praze / Fakulta elektrotechnická
http://linked.open...dnocenehoVysledku	257399
http://linked.open...ai/riv/idVysledku	RIV/68407700:21230/10:00167945
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	high-frequency activity; epilepsy; seizure onset; ripples; fast ripples; ictogenesis; temporal lobe epilepsy (en)
http://linked.open.../riv/klicoveSlovo	fast ripples temporal lobe epilepsy epilepsy high-frequency activity ictogenesis ripples seizure onset
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[E67F7A1F338D]
http://linked.open...i/riv/nazevZdroje	Brain
http://linked.open...in/vavai/riv/obor	FH
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	133
http://linked.open...iv/tvurceVysledku	Čmejla, Roman Jiruska, P. Finnerty, G. T. Jefferys, G. R. Lofti, N. Powell, A. D.
http://linked.open...ain/vavai/riv/wos	000277225700017
http://linked.open...n/vavai/riv/zamer	Transdisciplinární výzkum v oblasti biomedicínského inženýrství II
issn	0006-8950
number of pages	11 (xsd:int)
http://localhost/t...ganizacniJednotka	21230

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