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|---|
| rdf:type
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| rdfs:seeAlso
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| Description
| - Many people are stricken with degenerative osteochondral defects. osteochondral defects. Modern therapies of osteochondral defects are focused (for example) on the transplantation of osteochondral autografts, rushed spongiosa with collagen, chondrocytes and many others. The insertion of a crushed autologous bone graft has been reported as a possible therapy. However, the regenerative biomechanical (material) quality was less than 70% of healthy cartilage for fragments and controls. The transplantation of autologous osteochondral 3D-cylinders is one of several surgical therapies. During operations osteochondral defects are filled with material of a natural histological structure. However, the subchondral bone plates are interrupted and the biomechanical stability between the original tissue and the transplanted tissue is different. The biophysical and biochemical fixation of replacements and/or scaffolds to the tissue depends dominantly: (a) on the biomechanical properties and biochemical environments of the implants and the tissue; (b) on the stress-strain distributions in the tissue and the replacement, (c) on the organization and stability of collagen molecules adsorbed to modified surfaces of COC-blend replacements and (d) on the chondrogenesis on the hydrogel scaffold. Our activities were aimed at forming new articular cartilage and subchondral bone using biocompatible and bioconductive polymer replacements.
- Many people are stricken with degenerative osteochondral defects. osteochondral defects. Modern therapies of osteochondral defects are focused (for example) on the transplantation of osteochondral autografts, rushed spongiosa with collagen, chondrocytes and many others. The insertion of a crushed autologous bone graft has been reported as a possible therapy. However, the regenerative biomechanical (material) quality was less than 70% of healthy cartilage for fragments and controls. The transplantation of autologous osteochondral 3D-cylinders is one of several surgical therapies. During operations osteochondral defects are filled with material of a natural histological structure. However, the subchondral bone plates are interrupted and the biomechanical stability between the original tissue and the transplanted tissue is different. The biophysical and biochemical fixation of replacements and/or scaffolds to the tissue depends dominantly: (a) on the biomechanical properties and biochemical environments of the implants and the tissue; (b) on the stress-strain distributions in the tissue and the replacement, (c) on the organization and stability of collagen molecules adsorbed to modified surfaces of COC-blend replacements and (d) on the chondrogenesis on the hydrogel scaffold. Our activities were aimed at forming new articular cartilage and subchondral bone using biocompatible and bioconductive polymer replacements. (en)
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| Title
| - Hydrogel Scaffolds Contribute to the Osteogenesis and Chondrogenesis in the Small Osteochondral Defects
- Hydrogel Scaffolds Contribute to the Osteogenesis and Chondrogenesis in the Small Osteochondral Defects (en)
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| skos:prefLabel
| - Hydrogel Scaffolds Contribute to the Osteogenesis and Chondrogenesis in the Small Osteochondral Defects
- Hydrogel Scaffolds Contribute to the Osteogenesis and Chondrogenesis in the Small Osteochondral Defects (en)
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| skos:notation
| - RIV/68407700:21110/11:00189925!RIV12-MSM-21110___
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| http://linked.open...avai/riv/aktivita
| |
| http://linked.open...avai/riv/aktivity
| - P(GA106/06/0761), Z(MSM6840770012)
|
| http://linked.open...vai/riv/dodaniDat
| |
| http://linked.open...aciTvurceVysledku
| |
| http://linked.open.../riv/druhVysledku
| |
| http://linked.open...iv/duvernostUdaju
| |
| http://linked.open...titaPredkladatele
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| http://linked.open...dnocenehoVysledku
| |
| http://linked.open...ai/riv/idVysledku
| - RIV/68407700:21110/11:00189925
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| http://linked.open...riv/jazykVysledku
| |
| http://linked.open.../riv/klicovaSlova
| - articular cartilage; replacement; biomechanics; hzdrogel scaffolds; oteochondral defects (en)
|
| http://linked.open.../riv/klicoveSlovo
| |
| http://linked.open...ontrolniKodProRIV
| |
| http://linked.open...i/riv/mistoVydani
| |
| http://linked.open...i/riv/nazevZdroje
| - Biomaterials Applications for Nanomedicine
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| http://linked.open...in/vavai/riv/obor
| |
| http://linked.open...ichTvurcuVysledku
| |
| http://linked.open...v/pocetStranKnihy
| |
| http://linked.open...cetTvurcuVysledku
| |
| http://linked.open...vavai/riv/projekt
| |
| http://linked.open...UplatneniVysledku
| |
| http://linked.open...iv/tvurceVysledku
| - Danešová, Jana
- Hulejová, H.
- Kruliš, Z.
- Lísal, Jaroslav
- Petrtýl, Miroslav
- Černý, P.
- Bastl, Z.
- Polanská, M.
- Šenolt, L.
|
| http://linked.open...n/vavai/riv/zamer
| |
| number of pages
| |
| http://purl.org/ne...btex#hasPublisher
| |
| https://schema.org/isbn
| |
| http://localhost/t...ganizacniJednotka
| |
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