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  • The influence of spatially modulated high gradient magnetic fields on cellular functions of human THP-1 leukemia cells is studied. We demonstrate that arrays of high-gradient micrometer-sized magnets induce i) cell swelling, ii) prolonged increased ROS production, and iii) inhibit cell proliferation, and iv) elicit apoptosis of THP-1 monocytic leukemia cells in the absence of chemical or biological agents. Mathematical modeling indicates that mechanical stress exerted on the cells by high magnetic gradient forces is responsible for triggering cell swelling and formation of reactive oxygen species followed by apoptosis. We discuss physical aspects of controlling cell functions by focused magnetic gradient forces, i.e. by a noninvasive and nondestructive physical approach.
  • The influence of spatially modulated high gradient magnetic fields on cellular functions of human THP-1 leukemia cells is studied. We demonstrate that arrays of high-gradient micrometer-sized magnets induce i) cell swelling, ii) prolonged increased ROS production, and iii) inhibit cell proliferation, and iv) elicit apoptosis of THP-1 monocytic leukemia cells in the absence of chemical or biological agents. Mathematical modeling indicates that mechanical stress exerted on the cells by high magnetic gradient forces is responsible for triggering cell swelling and formation of reactive oxygen species followed by apoptosis. We discuss physical aspects of controlling cell functions by focused magnetic gradient forces, i.e. by a noninvasive and nondestructive physical approach. (en)
Title
  • Modulation of monocytic leukemia cell function and survival by highgradient magnetic fields and mathematical modeling studies
  • Modulation of monocytic leukemia cell function and survival by highgradient magnetic fields and mathematical modeling studies (en)
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  • Modulation of monocytic leukemia cell function and survival by highgradient magnetic fields and mathematical modeling studies
  • Modulation of monocytic leukemia cell function and survival by highgradient magnetic fields and mathematical modeling studies (en)
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  • RIV/68378271:_____/14:00427673!RIV15-AV0-68378271
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  • 30223
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  • RIV/68378271:_____/14:00427673
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  • magnetic field; cell proliferation; leukemia; apoptosis; modeling (en)
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  • GB - Spojené království Velké Británie a Severního Irska
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  • [FAB88970E899]
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  • Biomaterials
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  • 35
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  • Dejneka, Alexandr
  • Zablotskyy, Vitaliy A.
  • Simmet, T.
  • Syrovets, T.
  • Schmidt, Z.W.
http://linked.open...ain/vavai/riv/wos
  • 000332188400003
issn
  • 0142-9612
number of pages
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  • 10.1016/j.biomaterials.2013.12.098
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