About: Dual imaging probes for magnetic resonance imaging and fluorescence microscopy based on perovskite manganite nanoparticles

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About: Dual imaging probes for magnetic resonance imaging and fluorescence microscopy based on perovskite manganite nanoparticles Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The present study reveals the potential of magnetic nanoparticles based on the La0.75Sr0.25MnO3 perovskite manganite for MRI. Moreover, it describes the development of the dual imaging probe where the magnetic cores are combined with a fluorescent moiety while the improved colloidal stability is achieved by a two-ply silica shell. At first, the magnetic cores of La0.75Sr0.25MnO3 are coated with a hybrid silica layer, comprising a covalently attached fluorescein moiety that is subsequently covered by a pure silica layer providing the enhanced stability. Viability tests show that the complete particles are suitable for biological studies and the internalization occurs in different cell types. Further experiments prove no fatal interference with the vitality. Relaxometric measurements confirm high spin–spin relaxivities and visualisation of in vitro labeled pancreatic islets by MRI is successfully tested. The present study reveals the potential of magnetic nanoparticles based on the La0.75Sr0.25MnO3 perovskite manganite for MRI. Moreover, it describes the development of the dual imaging probe where the magnetic cores are combined with a fluorescent moiety while the improved colloidal stability is achieved by a two-ply silica shell. At first, the magnetic cores of La0.75Sr0.25MnO3 are coated with a hybrid silica layer, comprising a covalently attached fluorescein moiety that is subsequently covered by a pure silica layer providing the enhanced stability. Viability tests show that the complete particles are suitable for biological studies and the internalization occurs in different cell types. Further experiments prove no fatal interference with the vitality. Relaxometric measurements confirm high spin–spin relaxivities and visualisation of in vitro labeled pancreatic islets by MRI is successfully tested. (en)
Title	Dual imaging probes for magnetic resonance imaging and fluorescence microscopy based on perovskite manganite nanoparticles Dual imaging probes for magnetic resonance imaging and fluorescence microscopy based on perovskite manganite nanoparticles (en)
skos:prefLabel	Dual imaging probes for magnetic resonance imaging and fluorescence microscopy based on perovskite manganite nanoparticles Dual imaging probes for magnetic resonance imaging and fluorescence microscopy based on perovskite manganite nanoparticles (en)
skos:notation	RIV/68378271:_____/11:00358984!RIV12-AV0-68378271
http://linked.open...avai/riv/aktivita	P S Z
http://linked.open...avai/riv/aktivity	P(KAN200200651), P(KAN201110651), S, Z(AV0Z10100521), Z(AV0Z40720504), Z(AV0Z50390703), Z(MSM0021620857), Z(MSM0021620858)
http://linked.open...iv/cisloPeriodika	1
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Kaman, Ondřej Pollert, Emil Veverka, Pavel
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Fyzikální ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	195547
http://linked.open...ai/riv/idVysledku	RIV/68378271:_____/11:00358984
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	cellular labelling; dual probe; magnetic nanoparticles; MRI; silica coating (en)
http://linked.open.../riv/klicoveSlovo	magnetic nanoparticles MRI dual probe cellular labelling silica coating
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[3B1DD36BA507]
http://linked.open...i/riv/nazevZdroje	Journal of Materials Chemistry
http://linked.open...in/vavai/riv/obor	BM
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	14 (xsd:int)
http://linked.open...vavai/riv/projekt	Nanoparticulate and supramolecular systems for targeted drug delivery Combined contrast agents for molecular MR imaging
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	21
http://linked.open...iv/tvurceVysledku	Kotek, J. Kupčík, Jaroslav Zacharovová, K. Kaman, Ondřej Berková, A. Falteisek, L. Herynek, V. Jendelová, Pavla Jirák, D. Kačenka, M. Lukeš, I. Pollert, Emil Veverka, Pavel Černý, J.
http://linked.open...ain/vavai/riv/wos	000285067300019
http://linked.open...n/vavai/riv/zamer	Physics and technology of nanostructures, surfaces and thin films Investigation of multiphase reacting systems for the design of processes important in synthesis and preparation of novel materials, in energy production and in environmental protection New biotechnologies, nanomaterials and stem cells for use in regenerative medicine Nové molekulární systémy pro pokročilé aplikace prospěšné pro zdraví a šetrné k životnímu prostředí Signaling and cellular response mechanisms
issn	0959-9428
number of pages	8 (xsd:int)
http://bibframe.org/vocab/doi	10.1039/c0jm01258k

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