About: Activation of the protein kinase B and glycogen synthase kinase-3 signalling pathway during transient differentiation of human colon cancer HT-29 cells.

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About: Activation of the protein kinase B and glycogen synthase kinase-3 signalling pathway during transient differentiation of human colon cancer HT-29 cells. Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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Description	Using synthetic peptides which reproduce phosphoacceptor sites in the molecule of GSK-3, PKB an eIF2B, we found that phosphorylation and activity of PKB increased very early during in vitro differentiation induced by sodium butyrate. This was inhibited by wortmannin, the selective inhibitor of phosphoinositol-3 kinase, indicating that the control of PI3 kinase/PKB/GSK-3 signalling pathway is the early event of transient differentiation of the human colon cancer cells HT-29. Using synthetic peptides which reproduce phosphoacceptor sites in the molecule of GSK-3, PKB an eIF2B, we found that phosphorylation and activity of PKB increased very early during in vitro differentiation induced by sodium butyrate. This was inhibited by wortmannin, the selective inhibitor of phosphoinositol-3 kinase, indicating that the control of PI3 kinase/PKB/GSK-3 signalling pathway is the early event of transient differentiation of the human colon cancer cells HT-29. (en)
Title	Activation of the protein kinase B and glycogen synthase kinase-3 signalling pathway during transient differentiation of human colon cancer HT-29 cells. Activation of the protein kinase B and glycogen synthase kinase-3 signalling pathway during transient differentiation of human colon cancer HT-29 cells. (en)
skos:prefLabel	Activation of the protein kinase B and glycogen synthase kinase-3 signalling pathway during transient differentiation of human colon cancer HT-29 cells. Activation of the protein kinase B and glycogen synthase kinase-3 signalling pathway during transient differentiation of human colon cancer HT-29 cells. (en)
skos:notation	RIV/68378050:_____/99:23000246!RIV/2003/AV0/A23003/N
http://linked.open.../vavai/riv/strany	19;22
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA312/97/1188), P(GV312/96/K205), P(IZ3517), Z(AV0Z4055905), Z(AV0Z5052915)
http://linked.open...vai/riv/dodaniDat	2003
http://linked.open...aciTvurceVysledku	Sovová, Vlasta Tuháčková, Zdena Šloncová, Eva
http://linked.open.../riv/druhVysledku	D - Článek ve sborníku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav molekulární genetiky AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	734320
http://linked.open...ai/riv/idVysledku	RIV/68378050:_____/99:23000246
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	N/A (en)
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http://linked.open...v/mistoKonaniAkce	Praha [CZ]
http://linked.open...i/riv/mistoVydani	N/A
http://linked.open...i/riv/nazevZdroje	Collection. Symposium Series
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...ocetUcastnikuAkce	0 (xsd:int)
http://linked.open...nichUcastnikuAkce	0 (xsd:int)
http://linked.open...vavai/riv/projekt	Study of inhibitory mechanisms of pp60c-src during induced differentiation of colorectal tumour cells Gene src and related src family protein tyrosine kinases (PTK) involvement in cell signalling and differentiation and their pathogenic and oncogenic activities Signal transduction in lymphoid cells mediated by non-receptor protein tyrosine kinases of the Src and Syk families.
http://linked.open...UplatneniVysledku	1999
http://linked.open...iv/tvurceVysledku	Hlaváček, Jan Šloncová, Eva Velek, Jiří Tuháčková, Zdena Sovová, Vlasta
http://linked.open...vavai/riv/typAkce	WRD - Světová
http://linked.open.../riv/zahajeniAkce	1999-04-21 (xsd:date)
http://linked.open...n/vavai/riv/zamer	Chemical principles of selected biological phenomena in medicine and ecology Regulace a signální cesty uplatňující se v genové expresi, imunitě, onkogenezi, replikaci virů, tvorbě buněčných struktur, chování buněk, vývoji a oplození
number of pages	4 (xsd:int)
http://purl.org/ne...btex#hasPublisher	Neuveden

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