About: New method for recognition of sterol signalling molecules: Methinium salts as receptors for sulphated steroids

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	In this work, we studied indolium and benzothiazolium pentamethine salts 1-3 as novel type of receptors for the recognition of sulphated signalling molecules (sulphated steroids: oestrone, pregnenolone and cholesterol sulphate). A recognition study was performed in an aqueous medium (1mM phosphate buffer (H2O:MeOH; 99:1 (v/v))) at pH 7.34. The tested salts displayed a high affinity for these sulphated analytes, mainly for cholesterol sulphate. However, no interaction between the salts and control, non-sulphated sterol analytes (cholesterol and bile acid) was observed. The highest affinity for the sulphated steroids was observed for benzothiazole salt 1. This salt also displayed different spectral behaviour from that observed for carbocyanine salts 2 and 3. In this presence of cholesterol sulphate, benzothiazole salt 1 displayed significant spectral changes depending on the medium used: a blue shift in the aqueous medium and a red shift in the methanolic one (H2O:MeOH; 2:1 (v/v)). Subsequently preliminary in vivo study showed that, salt 1 significantly inhibits a growth of breast carcinoma on Nu/nu mice model. In this work, we studied indolium and benzothiazolium pentamethine salts 1-3 as novel type of receptors for the recognition of sulphated signalling molecules (sulphated steroids: oestrone, pregnenolone and cholesterol sulphate). A recognition study was performed in an aqueous medium (1mM phosphate buffer (H2O:MeOH; 99:1 (v/v))) at pH 7.34. The tested salts displayed a high affinity for these sulphated analytes, mainly for cholesterol sulphate. However, no interaction between the salts and control, non-sulphated sterol analytes (cholesterol and bile acid) was observed. The highest affinity for the sulphated steroids was observed for benzothiazole salt 1. This salt also displayed different spectral behaviour from that observed for carbocyanine salts 2 and 3. In this presence of cholesterol sulphate, benzothiazole salt 1 displayed significant spectral changes depending on the medium used: a blue shift in the aqueous medium and a red shift in the methanolic one (H2O:MeOH; 2:1 (v/v)). Subsequently preliminary in vivo study showed that, salt 1 significantly inhibits a growth of breast carcinoma on Nu/nu mice model. (en)
Title	New method for recognition of sterol signalling molecules: Methinium salts as receptors for sulphated steroids New method for recognition of sterol signalling molecules: Methinium salts as receptors for sulphated steroids (en)
skos:prefLabel	New method for recognition of sterol signalling molecules: Methinium salts as receptors for sulphated steroids New method for recognition of sterol signalling molecules: Methinium salts as receptors for sulphated steroids (en)
skos:notation	RIV/68378050:_____/15:00442567!RIV15-GA0-68378050
http://linked.open...avai/riv/aktivita	I P
http://linked.open...avai/riv/aktivity	I, P(ED1.1.00/02.0109), P(GAP303/11/1291)
http://linked.open...iv/cisloPeriodika	February 2015
http://linked.open...vai/riv/dodaniDat	2015
http://linked.open...aciTvurceVysledku	Králová, Jarmila
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav molekulární genetiky AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	306
http://linked.open...ai/riv/idVysledku	RIV/68378050:_____/15:00442567
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Polymethinium salts; Sulphated sterols; Molecular recognition; Synthetic receptors (en)
http://linked.open.../riv/klicoveSlovo	Molecular recognition Sulphated sterols Synthetic receptors Polymethinium salts
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[0972F19F0695]
http://linked.open...i/riv/nazevZdroje	Steroids
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	7 (xsd:int)
http://linked.open...vavai/riv/projekt	Biotechnology and Biomedicine Centre of the Academy of Sciences and Charles University New types of ligands interfering with cancer cell communication as a new therapeutic strategy
http://linked.open...UplatneniVysledku	2015
http://linked.open...v/svazekPeriodika	94
http://linked.open...iv/tvurceVysledku	Bříza, T. Kejík, Z. Král, V. Králová, Jarmila Martásek, P. Poučková, P. Mikula, I.
issn	1878-5867
number of pages	20 (xsd:int)
http://bibframe.org/vocab/doi	10.1016/j.steroids.2014.10.009

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