About: Striking antitumor activity of a methinium system with incorporated quinoxaline unit obtained by spontaneous cyclization

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About: Striking antitumor activity of a methinium system with incorporated quinoxaline unit obtained by spontaneous cyclization Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	A novel pentamethinium salt was synthesized with an unforeseen expanded conjugated quinoxaline unit directly incorporated into a pentamethinium chain. The compound exhibited high fluorescence intensity, selective mitochondrial localization, high cytotoxicity, and selectivity toward malignant cell lines, and resulted in remarkable in vivo suppression of tumor growth in mice. A novel pentamethinium salt was synthesized with an unforeseen expanded conjugated quinoxaline unit directly incorporated into a pentamethinium chain. The compound exhibited high fluorescence intensity, selective mitochondrial localization, high cytotoxicity, and selectivity toward malignant cell lines, and resulted in remarkable in vivo suppression of tumor growth in mice. (en)
Title	Striking antitumor activity of a methinium system with incorporated quinoxaline unit obtained by spontaneous cyclization Striking antitumor activity of a methinium system with incorporated quinoxaline unit obtained by spontaneous cyclization (en)
skos:prefLabel	Striking antitumor activity of a methinium system with incorporated quinoxaline unit obtained by spontaneous cyclization Striking antitumor activity of a methinium system with incorporated quinoxaline unit obtained by spontaneous cyclization (en)
skos:notation	RIV/68378050:_____/15:00442565!RIV15-GA0-68378050
http://linked.open...avai/riv/aktivita	I P
http://linked.open...avai/riv/aktivity	I, P(ED1.1.00/02.0109), P(GAP303/11/1291)
http://linked.open...iv/cisloPeriodika	4
http://linked.open...vai/riv/dodaniDat	2015
http://linked.open...aciTvurceVysledku	Králová, Jarmila
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav molekulární genetiky AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	442
http://linked.open...ai/riv/idVysledku	RIV/68378050:_____/15:00442565
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	cancer; methinium salt; quinoxaline (en)
http://linked.open.../riv/klicoveSlovo	cancer methinium salt quinoxaline
http://linked.open...odStatuVydavatele	DE - Spolková republika Německo
http://linked.open...ontrolniKodProRIV	[522FA594F79B]
http://linked.open...i/riv/nazevZdroje	Chembiochem : a European journal of chemical biology
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	12 (xsd:int)
http://linked.open...vavai/riv/projekt	Biotechnology and Biomedicine Centre of the Academy of Sciences and Charles University New types of ligands interfering with cancer cell communication as a new therapeutic strategy
http://linked.open...UplatneniVysledku	2015
http://linked.open...v/svazekPeriodika	16
http://linked.open...iv/tvurceVysledku	Bříza, T. Kejík, Z. Král, V. Králová, Jarmila Martásek, P. Poučková, P. Ruml, T. Dolenský, B. Džubák, P. Hajdúch, M. Rimpelová, S. Mikula, I.
issn	1439-7633
number of pages	4 (xsd:int)
http://bibframe.org/vocab/doi	10.1002/cbic.201402662

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