About: DISP3 promotes proliferation and delays differentiation of neural progenitor cells

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	DISP3 (PTCHD2), a sterol-sensing domain-containing protein, is highly expressed in neural tissue but its role in neural differentiation is unknown. In the present study we used a multipotent cerebellar progenitor cell line, C17.2, to investigate the impact of DISP3 on the proliferation and differentiation of neural precursors. We found that ectopically expressed DISP3 promotes cell proliferation and alters expression of genes that are involved in tumorigenesis. Finally, the differentiation profile of DISP3-expressing cells was altered, as evidenced by delayed expression of neural specific markers and a reduced capacity to undergo neural differentiation. DISP3 (PTCHD2), a sterol-sensing domain-containing protein, is highly expressed in neural tissue but its role in neural differentiation is unknown. In the present study we used a multipotent cerebellar progenitor cell line, C17.2, to investigate the impact of DISP3 on the proliferation and differentiation of neural precursors. We found that ectopically expressed DISP3 promotes cell proliferation and alters expression of genes that are involved in tumorigenesis. Finally, the differentiation profile of DISP3-expressing cells was altered, as evidenced by delayed expression of neural specific markers and a reduced capacity to undergo neural differentiation. (en)
Title	DISP3 promotes proliferation and delays differentiation of neural progenitor cells DISP3 promotes proliferation and delays differentiation of neural progenitor cells (en)
skos:prefLabel	DISP3 promotes proliferation and delays differentiation of neural progenitor cells DISP3 promotes proliferation and delays differentiation of neural progenitor cells (en)
skos:notation	RIV/68378050:_____/14:00436399!RIV15-GA0-68378050
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(GAP301/12/1478), P(LO1220)
http://linked.open...iv/cisloPeriodika	21
http://linked.open...vai/riv/dodaniDat	2015
http://linked.open...aciTvurceVysledku	Corlett, Alicia Ditrychová, Karolína Konířová, Jana Zíková, Martina Kolář, Michal Bartůněk, Petr
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav molekulární genetiky AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	11771
http://linked.open...ai/riv/idVysledku	RIV/68378050:_____/14:00436399
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Cancer; Proliferation; Neural cells; Differentiation; Lipids (en)
http://linked.open.../riv/klicoveSlovo	Neural cells Cancer Lipids Differentiation Proliferation
http://linked.open...odStatuVydavatele	NL - Nizozemsko
http://linked.open...ontrolniKodProRIV	[EB732AD9CE98]
http://linked.open...i/riv/nazevZdroje	FEBS Letters
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	6 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...vavai/riv/projekt	CZ-OPENSCREEN: National infrastructure for chemical biology The role of DISP3 protein in lipid metabolism
http://linked.open...UplatneniVysledku	2014
http://linked.open...v/svazekPeriodika	588
http://linked.open...iv/tvurceVysledku	Bartůněk, Petr Kolář, Michal Zíková, Martina Corlett, Alicia Ditrychová, Karolína Konířová, Jana
http://linked.open...ain/vavai/riv/wos	000344075400041
issn	0014-5793
number of pages	7 (xsd:int)
http://bibframe.org/vocab/doi	10.1016/j.febslet.2014.09.036

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