About: Genetic regulation of immunoglobulin E level in different pathological states: integration of mouse and human genetics

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Immunoglobulin E (IgE) first evolved in mammals. It plays an important role in defence against helminths and parasitic infection and in pathological states including allergic reactions, anti-tumour defence and autoimmune diseases. Elucidation of genetic control of IgE level could help us to understand regulation of the humoral immune response in health and disease, the etiology and pathogenesis of many human diseases, and to facilitate discovery of more effective methods for their prevention and cure. Herein we summarise progress in the genetics of regulation of IgE level in human diseases and show that integration of different approaches and use of animal models have synergistic effects in gaining new knowledge about both protective and pathological roles of this important antibody. Immunoglobulin E (IgE) first evolved in mammals. It plays an important role in defence against helminths and parasitic infection and in pathological states including allergic reactions, anti-tumour defence and autoimmune diseases. Elucidation of genetic control of IgE level could help us to understand regulation of the humoral immune response in health and disease, the etiology and pathogenesis of many human diseases, and to facilitate discovery of more effective methods for their prevention and cure. Herein we summarise progress in the genetics of regulation of IgE level in human diseases and show that integration of different approaches and use of animal models have synergistic effects in gaining new knowledge about both protective and pathological roles of this important antibody. (en)
Title	Genetic regulation of immunoglobulin E level in different pathological states: integration of mouse and human genetics Genetic regulation of immunoglobulin E level in different pathological states: integration of mouse and human genetics (en)
skos:prefLabel	Genetic regulation of immunoglobulin E level in different pathological states: integration of mouse and human genetics Genetic regulation of immunoglobulin E level in different pathological states: integration of mouse and human genetics (en)
skos:notation	RIV/68378050:_____/14:00434619!RIV15-GA0-68378050
http://linked.open...avai/riv/aktivita	I P
http://linked.open...avai/riv/aktivity	I, P(GA310/08/1697), P(LH12049)
http://linked.open...iv/cisloPeriodika	2
http://linked.open...vai/riv/dodaniDat	2015
http://linked.open...aciTvurceVysledku	Gusareva, Elena Kurey, Irina Lipoldová, Marie Grekov, Igor
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav molekulární genetiky AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	18101
http://linked.open...ai/riv/idVysledku	RIV/68378050:_____/14:00434619
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Genetic control of complex diseases; Immunoglobulin E; Epistasis (en)
http://linked.open.../riv/klicoveSlovo	Epistasis Genetic control of complex diseases Immunoglobulin E
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[88742F7DEA70]
http://linked.open...i/riv/nazevZdroje	Biological Reviews
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...vavai/riv/projekt	New Genomic Strategy for Rapid Identification of Genes Controlling Development of Infections and Cancer First genetic model for analysis of susceptibility to parasite Leishmania tropica: potential implications for studies of human leishmaniases
http://linked.open...UplatneniVysledku	2014
http://linked.open...v/svazekPeriodika	89
http://linked.open...iv/tvurceVysledku	Lipoldová, Marie Grekov, Igor Kurey, Irina Gusareva, Elena
http://linked.open...ain/vavai/riv/wos	000334182600007
issn	1464-7931
number of pages	31 (xsd:int)
http://bibframe.org/vocab/doi	10.1111/brv.12059

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