About: Rational design of chemical ligands for selective mitochondrial targeting

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The rational design of molecules with selective intracellular targeting is a great challenge for contemporary chemistry and life sciences. Here, we demonstrate a rational approach to development of compartment-specific fluorescent dyes from the gamma-aryl substituted pentamethine family. These novel dyes exhibit an extraordinary affinity and selectivity for cardiolipin in inner mitochondrial membrane and possess excellent photostability, fluorescent properties, and low phototoxicity. Selective imaging of live and fixed mitochondria was achieved in various cell lines using nanomolar concentrations of these dyes. Their high localization specificity and low toxicity enables study of morphological changes, structural complexity, and dynamics of mitochondria playing a pivotal role in many pathological diseases. These far-red emitting dyes could also serve in a variety of biomedical applications. The rational design of molecules with selective intracellular targeting is a great challenge for contemporary chemistry and life sciences. Here, we demonstrate a rational approach to development of compartment-specific fluorescent dyes from the gamma-aryl substituted pentamethine family. These novel dyes exhibit an extraordinary affinity and selectivity for cardiolipin in inner mitochondrial membrane and possess excellent photostability, fluorescent properties, and low phototoxicity. Selective imaging of live and fixed mitochondria was achieved in various cell lines using nanomolar concentrations of these dyes. Their high localization specificity and low toxicity enables study of morphological changes, structural complexity, and dynamics of mitochondria playing a pivotal role in many pathological diseases. These far-red emitting dyes could also serve in a variety of biomedical applications. (en)
Title	Rational design of chemical ligands for selective mitochondrial targeting Rational design of chemical ligands for selective mitochondrial targeting (en)
skos:prefLabel	Rational design of chemical ligands for selective mitochondrial targeting Rational design of chemical ligands for selective mitochondrial targeting (en)
skos:notation	RIV/68378050:_____/13:00423290!RIV14-GA0-68378050
http://linked.open...avai/riv/aktivita	I P S
http://linked.open...avai/riv/aktivity	I, P(GA203/09/1311), P(GAP303/11/1291), P(KAN200100801), S
http://linked.open...iv/cisloPeriodika	9
http://linked.open...vai/riv/dodaniDat	2014
http://linked.open...aciTvurceVysledku	Králová, Jarmila
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav molekulární genetiky AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	101520
http://linked.open...ai/riv/idVysledku	RIV/68378050:_____/13:00423290
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	intracellular targeting; mitochondria; cardiolipin; pentamethine; fluorescent dyes (en)
http://linked.open.../riv/klicoveSlovo	fluorescent dyes mitochondria cardiolipin intracellular targeting pentamethine
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[D0B3F2F8610C]
http://linked.open...i/riv/nazevZdroje	Bioconjugate chemistry
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	9 (xsd:int)
http://linked.open...vavai/riv/projekt	Synthetic probes for recognition of tumor markers:applications for cell directed apoptosis and targeted photodynamic therapy New types of ligands interfering with cancer cell communication as a new therapeutic strategy Bioactive Biocompatible Surfaces and Novel Nanostructured Composites for Applications to Medicine and Drug Delivery
http://linked.open...UplatneniVysledku	2013
http://linked.open...v/svazekPeriodika	24
http://linked.open...iv/tvurceVysledku	Bříza, T. Císařová, I. Kejík, Z. Král, V. Králová, Jarmila Martásek, P. Ruml, T. Rimpelová, S. Záruba, K.
http://linked.open...ain/vavai/riv/wos	000330097800004
issn	1520-4812
number of pages	10 (xsd:int)
http://bibframe.org/vocab/doi	10.1021/bc400291f

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