About: Expression of human BRCA1 Delta 17-19 alternative splicing variant with a truncated BRCT domain in MCF-7 cells results in impaired assembly of DNA repair complexes and aberrant DNA damage response

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About: Expression of human BRCA1 Delta 17-19 alternative splicing variant with a truncated BRCT domain in MCF-7 cells results in impaired assembly of DNA repair complexes and aberrant DNA damage response Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Alternative pre-mRNA splicing is a fundamental post-transcriptional regulatory mechanism. Cancer-specific misregulation of the splicing process may lead to formation of irregular alternative splicing variants (ASVs) with a potentially negative impact on cellular homeostasis. Alternative splicing of BRCA1 pre-mRNA can give rise to BRCA1 protein isoforms that possess dramatically altered biological activities compared with full-length wild-type BRCAl. During the screening of high-risk breast cancer (BC) families we ascertained numerous BRCA1 ASVs, however, their clinical significance for BC development is largely unknown. In this study, we examined the influence of the BRCA1 Delta 17-19 ASV, which lacks a portion of the BRCT domain, on DNA repair capacity using human MCF-7 BC cell clones with stably modified BRCA1 expression. Alternative pre-mRNA splicing is a fundamental post-transcriptional regulatory mechanism. Cancer-specific misregulation of the splicing process may lead to formation of irregular alternative splicing variants (ASVs) with a potentially negative impact on cellular homeostasis. Alternative splicing of BRCA1 pre-mRNA can give rise to BRCA1 protein isoforms that possess dramatically altered biological activities compared with full-length wild-type BRCAl. During the screening of high-risk breast cancer (BC) families we ascertained numerous BRCA1 ASVs, however, their clinical significance for BC development is largely unknown. In this study, we examined the influence of the BRCA1 Delta 17-19 ASV, which lacks a portion of the BRCT domain, on DNA repair capacity using human MCF-7 BC cell clones with stably modified BRCA1 expression. (en)
Title	Expression of human BRCA1 Delta 17-19 alternative splicing variant with a truncated BRCT domain in MCF-7 cells results in impaired assembly of DNA repair complexes and aberrant DNA damage response Expression of human BRCA1 Delta 17-19 alternative splicing variant with a truncated BRCT domain in MCF-7 cells results in impaired assembly of DNA repair complexes and aberrant DNA damage response (en)
skos:prefLabel	Expression of human BRCA1 Delta 17-19 alternative splicing variant with a truncated BRCT domain in MCF-7 cells results in impaired assembly of DNA repair complexes and aberrant DNA damage response Expression of human BRCA1 Delta 17-19 alternative splicing variant with a truncated BRCT domain in MCF-7 cells results in impaired assembly of DNA repair complexes and aberrant DNA damage response (en)
skos:notation	RIV/68378050:_____/13:00394847!RIV14-GA0-68378050
http://linked.open...avai/riv/aktivita	I P S
http://linked.open...avai/riv/aktivity	I, P(ED0030/01/01), P(GAP301/10/1525), P(GAP301/12/1850), P(GBP302/12/G157), P(NT11065), P(NT12280), S
http://linked.open...iv/cisloPeriodika	5
http://linked.open...vai/riv/dodaniDat	2014
http://linked.open...aciTvurceVysledku	Bártek, Jiří Macůrek, Libor Hodný, Zdeněk
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav molekulární genetiky AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	74350
http://linked.open...ai/riv/idVysledku	RIV/68378050:_____/13:00394847
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	STRAND BREAK REPAIR; INDUCED NUCLEAR FOCI; OVARIAN-CANCER (en)
http://linked.open.../riv/klicoveSlovo	STRAND BREAK REPAIR INDUCED NUCLEAR FOCI OVARIAN-CANCER
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[67132CB4B0BA]
http://linked.open...i/riv/nazevZdroje	Cellular Signalling
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	14 (xsd:int)
http://linked.open...vavai/riv/projekt	BRCA1 alternative splicing variants and their prognostic and predictive role in breast cancer Biomedicine for regional development and human resources Functional analysis of the BRCA1 alternative splicing variants in vitro and their relationship to the mammary carcinogenesis. Dynamics and Organization of Chromosomes in the Cell Cycle and during Differentiation under Normal and Pathological Conditions Mechanisms of DNA damage checkpoint termination Analysis and targeting of DNA damage signaling and repair mechanisms in glioblastomas and glioblastoma stem cells as a strategy to elucidate pathogenesis and search for individualized targeted treatments combined with standard therapy
http://linked.open...UplatneniVysledku	2013
http://linked.open...v/svazekPeriodika	25
http://linked.open...iv/tvurceVysledku	Macůrek, Libor Ševčík, J. Falk, Martin Hodný, Zdeněk Bartek, Jiří Štefančíková, Lenka Janatová, M. Kleibl, Z. Kleiblová, P. Lhota, F. Pohlreich, P. Hojný, J. Ježková, L. Stříbrná, J.
http://linked.open...ain/vavai/riv/wos	000318377300016
issn	0898-6568
number of pages	8 (xsd:int)
http://bibframe.org/vocab/doi	10.1016/j.cellsig.2013.02.008

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