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Description
| - The canonical RNA interference (RNAi) pathway is defined as a sequence-specific mRNA degradation mediated by short RNA molecules which are generated from long double-stranded RNA. Since its discovery in 1998, RNAi has become a popular tool for experimental silencing of gene expression. On the other hand, its natural role received less attention. Recent studies in animal systems, particularly the use of the next generation sequencing and analysis of animals defective in some aspect of small RNA biogenesis, revealed novel functions of RNAi and cross talks between RNAi and other pathways employing small RNAs. This chapter provides a comprehensive view of the natural canonical RNAi pathway in animals including its molecular mechanism and different biological roles.
- The canonical RNA interference (RNAi) pathway is defined as a sequence-specific mRNA degradation mediated by short RNA molecules which are generated from long double-stranded RNA. Since its discovery in 1998, RNAi has become a popular tool for experimental silencing of gene expression. On the other hand, its natural role received less attention. Recent studies in animal systems, particularly the use of the next generation sequencing and analysis of animals defective in some aspect of small RNA biogenesis, revealed novel functions of RNAi and cross talks between RNAi and other pathways employing small RNAs. This chapter provides a comprehensive view of the natural canonical RNAi pathway in animals including its molecular mechanism and different biological roles. (en)
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Title
| - The canonical RNA interference pathway in animals
- The canonical RNA interference pathway in animals (en)
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skos:prefLabel
| - The canonical RNA interference pathway in animals
- The canonical RNA interference pathway in animals (en)
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skos:notation
| - RIV/68378050:_____/12:00390170!RIV13-AV0-68378050
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http://linked.open...avai/riv/aktivita
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http://linked.open...avai/riv/aktivity
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http://linked.open...vai/riv/dodaniDat
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http://linked.open...aciTvurceVysledku
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http://linked.open.../riv/druhVysledku
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http://linked.open...iv/duvernostUdaju
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http://linked.open...titaPredkladatele
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http://linked.open...dnocenehoVysledku
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http://linked.open...ai/riv/idVysledku
| - RIV/68378050:_____/12:00390170
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http://linked.open...riv/jazykVysledku
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http://linked.open.../riv/klicovaSlova
| - Argonaute; Dicer; dsRNA; RNAi; siRNA (en)
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http://linked.open.../riv/klicoveSlovo
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http://linked.open...ontrolniKodProRIV
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http://linked.open...i/riv/mistoVydani
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http://linked.open...i/riv/nazevZdroje
| - Regulatory RNAs: Basics, Methods and Applications
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http://linked.open...in/vavai/riv/obor
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http://linked.open...ichTvurcuVysledku
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http://linked.open...v/pocetStranKnihy
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http://linked.open...cetTvurcuVysledku
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http://linked.open...UplatneniVysledku
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http://linked.open...iv/tvurceVysledku
| - Svoboda, Petr
- Flemr, Matyáš
- Nejepínská, Jana
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http://linked.open...n/vavai/riv/zamer
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number of pages
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http://bibframe.org/vocab/doi
| - 10.1007/978-3-642-22517-8_5
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http://purl.org/ne...btex#hasPublisher
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https://schema.org/isbn
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