About: The canonical RNA interference pathway in animals

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The canonical RNA interference (RNAi) pathway is defined as a sequence-specific mRNA degradation mediated by short RNA molecules which are generated from long double-stranded RNA. Since its discovery in 1998, RNAi has become a popular tool for experimental silencing of gene expression. On the other hand, its natural role received less attention. Recent studies in animal systems, particularly the use of the next generation sequencing and analysis of animals defective in some aspect of small RNA biogenesis, revealed novel functions of RNAi and cross talks between RNAi and other pathways employing small RNAs. This chapter provides a comprehensive view of the natural canonical RNAi pathway in animals including its molecular mechanism and different biological roles. The canonical RNA interference (RNAi) pathway is defined as a sequence-specific mRNA degradation mediated by short RNA molecules which are generated from long double-stranded RNA. Since its discovery in 1998, RNAi has become a popular tool for experimental silencing of gene expression. On the other hand, its natural role received less attention. Recent studies in animal systems, particularly the use of the next generation sequencing and analysis of animals defective in some aspect of small RNA biogenesis, revealed novel functions of RNAi and cross talks between RNAi and other pathways employing small RNAs. This chapter provides a comprehensive view of the natural canonical RNAi pathway in animals including its molecular mechanism and different biological roles. (en)
Title	The canonical RNA interference pathway in animals The canonical RNA interference pathway in animals (en)
skos:prefLabel	The canonical RNA interference pathway in animals The canonical RNA interference pathway in animals (en)
skos:notation	RIV/68378050:_____/12:00390170!RIV13-AV0-68378050
http://linked.open...avai/riv/aktivita	I Z
http://linked.open...avai/riv/aktivity	I, Z(AV0Z50520514)
http://linked.open...vai/riv/dodaniDat	2013
http://linked.open...aciTvurceVysledku	Flemr, Matyáš Svoboda, Petr Nejepínská, Jana
http://linked.open.../riv/druhVysledku	C - Kapitola v knize
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav molekulární genetiky AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	125930
http://linked.open...ai/riv/idVysledku	RIV/68378050:_____/12:00390170
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Argonaute; Dicer; dsRNA; RNAi; siRNA (en)
http://linked.open.../riv/klicoveSlovo	RNAi Argonaute Dicer dsRNA siRNA
http://linked.open...ontrolniKodProRIV	[23BE43790DCA]
http://linked.open...i/riv/mistoVydani	Berlin - Heidelberg
http://linked.open...i/riv/nazevZdroje	Regulatory RNAs: Basics, Methods and Applications
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...v/pocetStranKnihy	552 (xsd:int)
http://linked.open...cetTvurcuVysledku	3 (xsd:int)
http://linked.open...UplatneniVysledku	2012
http://linked.open...iv/tvurceVysledku	Svoboda, Petr Flemr, Matyáš Nejepínská, Jana
http://linked.open...n/vavai/riv/zamer	Molekulárně genetické a buněčné základy klíčových biologických procesů: genová exprese, onkogeneze, replikace virů, imunita a vývoj organismů
number of pages	39 (xsd:int)
http://bibframe.org/vocab/doi	10.1007/978-3-642-22517-8_5
http://purl.org/ne...btex#hasPublisher	Springer-Verlag
https://schema.org/isbn	978-3-642-22516-1

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