About: Signal transduction pathways participating in homeostasis and malignant transformation of the intestinal tissue

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About: Signal transduction pathways participating in homeostasis and malignant transformation of the intestinal tissue Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Intestinal homeostasis is a complex and tightly regulated process governed by a variety of signalling pathways that balance cell proliferation and differentiation. As revealed by extensive use of defined mouse models, perturbations within the signalling circuitry trigger initial expansion of premalignant cells. In this review, we attempt to summarise recent advances in the knowledge of the cellular signalling mechanisms that drive tumorigenesis in the human and mouse intestine. Intestinal homeostasis is a complex and tightly regulated process governed by a variety of signalling pathways that balance cell proliferation and differentiation. As revealed by extensive use of defined mouse models, perturbations within the signalling circuitry trigger initial expansion of premalignant cells. In this review, we attempt to summarise recent advances in the knowledge of the cellular signalling mechanisms that drive tumorigenesis in the human and mouse intestine. (en)
Title	Signal transduction pathways participating in homeostasis and malignant transformation of the intestinal tissue Signal transduction pathways participating in homeostasis and malignant transformation of the intestinal tissue (en)
skos:prefLabel	Signal transduction pathways participating in homeostasis and malignant transformation of the intestinal tissue Signal transduction pathways participating in homeostasis and malignant transformation of the intestinal tissue (en)
skos:notation	RIV/68378050:_____/12:00383116!RIV13-GA0-68378050
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(GAP304/11/1252), P(GAP305/11/1780), P(GAP305/12/2347), P(GD204/09/H058)
http://linked.open...iv/cisloPeriodika	6
http://linked.open...vai/riv/dodaniDat	2013
http://linked.open...aciTvurceVysledku	Kořínek, Vladimír Krausová, Michaela
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav molekulární genetiky AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	167810
http://linked.open...ai/riv/idVysledku	RIV/68378050:_____/12:00383116
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	colorectal cancer; epithelium; gut; intestine; mouse models; stem cells (en)
http://linked.open.../riv/klicoveSlovo	stem cells colorectal cancer intestine epithelium mouse models gut
http://linked.open...odStatuVydavatele	SK - Slovenská republika
http://linked.open...ontrolniKodProRIV	[385BA5FB6AAD]
http://linked.open...i/riv/nazevZdroje	Neoplasma
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	2 (xsd:int)
http://linked.open...vavai/riv/projekt	Bacteria in etiology, prevention ant therapy of experimentally induced intestinal inflammation and colon cancer Intercellular signalling in development and disease Wnt signaling in self-renewal and tumorigenesis of the intestinal epithelia Molecular mechanisms of the tumor suppressor function of the HIC1 gene
http://linked.open...UplatneniVysledku	2012
http://linked.open...v/svazekPeriodika	59
http://linked.open...iv/tvurceVysledku	Kořínek, Vladimír Krausová, Michaela
http://linked.open...ain/vavai/riv/wos	000310820200015
issn	0028-2685
number of pages	11 (xsd:int)
http://bibframe.org/vocab/doi	10.4149/neo_2012_090

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