About: Control of the interferon response in RNAi experiments

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The RNA interference (RNAi) and interferons have been an uneasy marriage. Ever since the discovery of RNAi in mammals, the interferon response has been a feared problem. While RNAi became an efficient and widespread method for gene silencing in mammals, numerous studies recognized several obstacles, including undesirable activation of the interferon response, which need to be overcome to achieve a specific and robust RNAi effect. The aim of this text is to provide theoretical and practical information for scientists who want to control interferon response and other adverse effects in their RNAi experiments. The RNA interference (RNAi) and interferons have been an uneasy marriage. Ever since the discovery of RNAi in mammals, the interferon response has been a feared problem. While RNAi became an efficient and widespread method for gene silencing in mammals, numerous studies recognized several obstacles, including undesirable activation of the interferon response, which need to be overcome to achieve a specific and robust RNAi effect. The aim of this text is to provide theoretical and practical information for scientists who want to control interferon response and other adverse effects in their RNAi experiments. (en)
Title	Control of the interferon response in RNAi experiments Control of the interferon response in RNAi experiments (en)
skos:prefLabel	Control of the interferon response in RNAi experiments Control of the interferon response in RNAi experiments (en)
skos:notation	RIV/68378050:_____/12:00371730!RIV12-AV0-68378050
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA204/09/0085), P(IAA501110701), Z(AV0Z50520514)
http://linked.open...iv/cisloPeriodika	-
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Flemr, Matyáš Svoboda, Petr Nejepínská, Jana
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav molekulární genetiky AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	128699
http://linked.open...ai/riv/idVysledku	RIV/68378050:_____/12:00371730
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	RNAi; interferon; siRNA (en)
http://linked.open.../riv/klicoveSlovo	RNAi siRNA interferon
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[55C2BCB077BB]
http://linked.open...i/riv/nazevZdroje	Methods in Molecular Biology
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	3 (xsd:int)
http://linked.open...vavai/riv/projekt	RNA silencing and long dsRNA in mammalian cells Activity and silencing of mobile elements in mammalian cells.
http://linked.open...UplatneniVysledku	2012
http://linked.open...v/svazekPeriodika	820
http://linked.open...iv/tvurceVysledku	Svoboda, Petr Flemr, Matyáš Nejepínská, Jana
http://linked.open...n/vavai/riv/zamer	Molekulárně genetické a buněčné základy klíčových biologických procesů: genová exprese, onkogeneze, replikace virů, imunita a vývoj organismů
issn	1064-3745
number of pages	29 (xsd:int)
http://bibframe.org/vocab/doi	10.1007/978-1-61779-439-1_9

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