About: Targeting beta III-tubulin in glioblastoma multiforme: from cell biology and histopathology to cancer therapeutics

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About: Targeting beta III-tubulin in glioblastoma multiforme: from cell biology and histopathology to cancer therapeutics Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Glioblastoma multiforme (GBM) is the most common, aggressive, and chemorefractory brain tumor in human adults. Notwithstanding significant discoveries in the elucidation of signaling pathways and genetics of GBM during the past 20 years there has been no breakthrough in the pharmacological treatment of this high-grade malignancy. We have previously demonstrated increased expression of βIII-tubulin in GBM asserting a link between aberrant expression of βIII-tubulin and a disruption of microtubule dynamics associated either with malignant tumor development de novo, or with malignant transformation of a low-grade glioma into GBM. This article reviews βIII-tubulin as a promising target in the experimental treatment of GBM and examines the potential use of epothilones, a new family of anticancer agents shown to be active in βIII-tubulin-expressing tumor cells. Glioblastoma multiforme (GBM) is the most common, aggressive, and chemorefractory brain tumor in human adults. Notwithstanding significant discoveries in the elucidation of signaling pathways and genetics of GBM during the past 20 years there has been no breakthrough in the pharmacological treatment of this high-grade malignancy. We have previously demonstrated increased expression of βIII-tubulin in GBM asserting a link between aberrant expression of βIII-tubulin and a disruption of microtubule dynamics associated either with malignant tumor development de novo, or with malignant transformation of a low-grade glioma into GBM. This article reviews βIII-tubulin as a promising target in the experimental treatment of GBM and examines the potential use of epothilones, a new family of anticancer agents shown to be active in βIII-tubulin-expressing tumor cells. (en)
Title	Targeting beta III-tubulin in glioblastoma multiforme: from cell biology and histopathology to cancer therapeutics Targeting beta III-tubulin in glioblastoma multiforme: from cell biology and histopathology to cancer therapeutics (en)
skos:prefLabel	Targeting beta III-tubulin in glioblastoma multiforme: from cell biology and histopathology to cancer therapeutics Targeting beta III-tubulin in glioblastoma multiforme: from cell biology and histopathology to cancer therapeutics (en)
skos:notation	RIV/68378050:_____/11:00378912!RIV13-GA0-68378050
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GAP302/10/1759), Z(AV0Z50520514)
http://linked.open...iv/cisloPeriodika	8
http://linked.open...vai/riv/dodaniDat	2013
http://linked.open...aciTvurceVysledku	Dráber, Pavel
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav molekulární genetiky AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	234215
http://linked.open...ai/riv/idVysledku	RIV/68378050:_____/11:00378912
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	glioblastoma multiforme; tubulin binding agent; epothilones (en)
http://linked.open.../riv/klicoveSlovo	epothilones tubulin binding agent glioblastoma multiforme
http://linked.open...odStatuVydavatele	NL - Nizozemsko
http://linked.open...ontrolniKodProRIV	[FC041EB2D511]
http://linked.open...i/riv/nazevZdroje	Anti-Cancer Agents in Medicinal Chemistry
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	3 (xsd:int)
http://linked.open...vavai/riv/projekt	Function-structure relationships between transmembrane adaptor-based signalosomes in mast cells
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	11
http://linked.open...iv/tvurceVysledku	Dráber, Pavel Katsetos, C. D. Kavallaris, M.
http://linked.open...ain/vavai/riv/wos	000298057800005
http://linked.open...n/vavai/riv/zamer	Molekulárně genetické a buněčné základy klíčových biologických procesů: genová exprese, onkogeneze, replikace virů, imunita a vývoj organismů
issn	1871-5206
number of pages	10 (xsd:int)

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