About: BRAF and RAS oncogenes regulate Rho GTPase pathways to mediate migration and invasion properties in human colon cancer cells: a comparative study

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About: BRAF and RAS oncogenes regulate Rho GTPase pathways to mediate migration and invasion properties in human colon cancer cells: a comparative study Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Colorectal cancer is a common disease that involves genetic alterations, such as inactivation of tumour suppressor genes and activation of oncogenes such as or BRAF. The aim of this study is to dissect cell migration and invasion pathways that are utilised by BRAFV600E and mutated RAS oncoproteins. Colon adenocarcinoma cells with endogenous as well as ectopically expressed or silenced oncogenic mutations of BRAFV600E, KRASG12V and HRASG12V were employed. BRAFV600E significantly induces cell migration and invasion of colon cancer cells partly via activation of RhoA GTPase. KRASG12V enhances the ability of colon adenocarcinoma cells Caco-2 to migrate and invade through filopodia formation. Increased cell migration and invasion, mediated by Rac1 and mesenchymal morphology were the main characteristics rendered by HRASG12V in Caco-2 cells. RAS oncogenes can also cooperate with the TGFbeta-1 pathway in cellular transformation. Colorectal cancer is a common disease that involves genetic alterations, such as inactivation of tumour suppressor genes and activation of oncogenes such as or BRAF. The aim of this study is to dissect cell migration and invasion pathways that are utilised by BRAFV600E and mutated RAS oncoproteins. Colon adenocarcinoma cells with endogenous as well as ectopically expressed or silenced oncogenic mutations of BRAFV600E, KRASG12V and HRASG12V were employed. BRAFV600E significantly induces cell migration and invasion of colon cancer cells partly via activation of RhoA GTPase. KRASG12V enhances the ability of colon adenocarcinoma cells Caco-2 to migrate and invade through filopodia formation. Increased cell migration and invasion, mediated by Rac1 and mesenchymal morphology were the main characteristics rendered by HRASG12V in Caco-2 cells. RAS oncogenes can also cooperate with the TGFbeta-1 pathway in cellular transformation. (en)
Title	BRAF and RAS oncogenes regulate Rho GTPase pathways to mediate migration and invasion properties in human colon cancer cells: a comparative study BRAF and RAS oncogenes regulate Rho GTPase pathways to mediate migration and invasion properties in human colon cancer cells: a comparative study (en)
skos:prefLabel	BRAF and RAS oncogenes regulate Rho GTPase pathways to mediate migration and invasion properties in human colon cancer cells: a comparative study BRAF and RAS oncogenes regulate Rho GTPase pathways to mediate migration and invasion properties in human colon cancer cells: a comparative study (en)
skos:notation	RIV/68378050:_____/11:00371711!RIV12-AV0-68378050
http://linked.open...avai/riv/aktivita	Z
http://linked.open...avai/riv/aktivity	Z(AV0Z50520514)
http://linked.open...iv/cisloPeriodika	-
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Koc, Michal Anděra, Ladislav
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav molekulární genetiky AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	188688
http://linked.open...ai/riv/idVysledku	RIV/68378050:_____/11:00371711
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	colorectal cancer; invasiveness; oncogenes (en)
http://linked.open.../riv/klicoveSlovo	colorectal cancer invasiveness oncogenes
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[54B5E0B691A5]
http://linked.open...i/riv/nazevZdroje	Molecular Cancer
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	7 (xsd:int)
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	10
http://linked.open...iv/tvurceVysledku	Anděra, Ladislav Koc, Michal Makrodouli, E. Oikonomou, E. Pintzas, A. Sasazuki, T. Shirasawa, S.
http://linked.open...ain/vavai/riv/wos	000295831300001
http://linked.open...n/vavai/riv/zamer	Molekulárně genetické a buněčné základy klíčových biologických procesů: genová exprese, onkogeneze, replikace virů, imunita a vývoj organismů
issn	1476-4598
number of pages	21 (xsd:int)
http://bibframe.org/vocab/doi	10.1186/1476-4598-10-118

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