About: T-cell activation triggers death receptor-6 expression in a NF-kappa B and NF-AT dependent manner     Goto   Sponge   NotDistinct   Permalink

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  • Death receptor-6 (DR6) participates in the regulation of T-cell activation and/or activity as its genetic disruption results in enhanced CD4+ T-cell expansion, the production of Th2 cytokines, and interestingly also the compromised migration of CD4+ T cells to sites of inflammation. In this communication we show that DR6 is not expressed in resting T cells from human peripheral blood or murine lymph nodes but that its expression is significantly upregulated in CD3 crosslinking- or PMA/ionomycin-activated T lymphocytes. DR6 expression is transiently increased in both activated human CD4+ and CD8+ T cells and it is apparently dependent on the activation of NF-kappaB and NF-AT signaling pathways. In contrast to primary peripheral blood T cells, the widely used model lymphoblastic leukemia T-cell line Jurkat is DR6-positive and unexpectedly, TCR-mediated stimulation of Jurkat cells strongly downregulates DR6 expression via suppression of its transcription.
  • Death receptor-6 (DR6) participates in the regulation of T-cell activation and/or activity as its genetic disruption results in enhanced CD4+ T-cell expansion, the production of Th2 cytokines, and interestingly also the compromised migration of CD4+ T cells to sites of inflammation. In this communication we show that DR6 is not expressed in resting T cells from human peripheral blood or murine lymph nodes but that its expression is significantly upregulated in CD3 crosslinking- or PMA/ionomycin-activated T lymphocytes. DR6 expression is transiently increased in both activated human CD4+ and CD8+ T cells and it is apparently dependent on the activation of NF-kappaB and NF-AT signaling pathways. In contrast to primary peripheral blood T cells, the widely used model lymphoblastic leukemia T-cell line Jurkat is DR6-positive and unexpectedly, TCR-mediated stimulation of Jurkat cells strongly downregulates DR6 expression via suppression of its transcription. (en)
Title
  • T-cell activation triggers death receptor-6 expression in a NF-kappa B and NF-AT dependent manner
  • T-cell activation triggers death receptor-6 expression in a NF-kappa B and NF-AT dependent manner (en)
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  • T-cell activation triggers death receptor-6 expression in a NF-kappa B and NF-AT dependent manner
  • T-cell activation triggers death receptor-6 expression in a NF-kappa B and NF-AT dependent manner (en)
skos:notation
  • RIV/68378050:_____/11:00371708!RIV12-AV0-68378050
http://linked.open...avai/riv/aktivita
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  • P(1M0506), Z(AV0Z50520514)
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  • 12-13
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  • 234264
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  • RIV/68378050:_____/11:00371708
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  • TNFRSF21; T cells; Jurkat (en)
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  • GB - Spojené království Velké Británie a Severního Irska
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  • [9F3A07B3D416]
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  • Molecular Immunology
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  • 48
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  • Anděra, Ladislav
  • Koc, Michal
  • Broučková, Adéla
  • Klíma, Martin
http://linked.open...ain/vavai/riv/wos
  • 000292444100011
http://linked.open...n/vavai/riv/zamer
issn
  • 0161-5890
number of pages
http://bibframe.org/vocab/doi
  • 10.1016/j.molimm.2011.03.021
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