About: Expression and regulation of murine SPINK12, a potential orthologue of human LEKTI2

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About: Expression and regulation of murine SPINK12, a potential orthologue of human LEKTI2 Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	We describe expression and regulation of murine SPINK12, potential orthologue of human LEKTI2. Its expression was analysed by RT-PCR and immunohistochemistry revealing organ-specific pattern with high level of expression in epidermis and several epithelia including stomach, kidney and uterus. mSPINK12 expression in skin epidermis at footpads, where stratification is markedly pronounced, was several folds higher than in the abdominal epidermis. mSPINK12 mRNA levels were not affected by any cytokines tested while treatment of primary murine keratinocytes with the combination of calcium and sorbitol resulted in a strong increase in its mRNA. mspink12 seems especially expressed in the epidermal areas with thick skin and its regulation generally responds to differentiation signals. mrSPINK12 shows inhibitory activity against murine keratinocyte-derived trypsin-like proteolytic activity and appears orthologous to human LEKTI2, with possible role in regulation of epithelial cell functions. We describe expression and regulation of murine SPINK12, potential orthologue of human LEKTI2. Its expression was analysed by RT-PCR and immunohistochemistry revealing organ-specific pattern with high level of expression in epidermis and several epithelia including stomach, kidney and uterus. mSPINK12 expression in skin epidermis at footpads, where stratification is markedly pronounced, was several folds higher than in the abdominal epidermis. mSPINK12 mRNA levels were not affected by any cytokines tested while treatment of primary murine keratinocytes with the combination of calcium and sorbitol resulted in a strong increase in its mRNA. mspink12 seems especially expressed in the epidermal areas with thick skin and its regulation generally responds to differentiation signals. mrSPINK12 shows inhibitory activity against murine keratinocyte-derived trypsin-like proteolytic activity and appears orthologous to human LEKTI2, with possible role in regulation of epithelial cell functions. (en)
Title	Expression and regulation of murine SPINK12, a potential orthologue of human LEKTI2 Expression and regulation of murine SPINK12, a potential orthologue of human LEKTI2 (en)
skos:prefLabel	Expression and regulation of murine SPINK12, a potential orthologue of human LEKTI2 Expression and regulation of murine SPINK12, a potential orthologue of human LEKTI2 (en)
skos:notation	RIV/68378050:_____/11:00371299!RIV12-AV0-68378050
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GC301/08/J053), Z(AV0Z50520514)
http://linked.open...iv/cisloPeriodika	11
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Sedláček, Radislav Křenek, Pavel Suchanová, Šárka Buryová, Halka Brauer, Rena
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav molekulární genetiky AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	199017
http://linked.open...ai/riv/idVysledku	RIV/68378050:_____/11:00371299
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	epidermis; inhibitor; kallikrein; serine protease; spink (en)
http://linked.open.../riv/klicoveSlovo	epidermis kallikrein serine protease spink inhibitor
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[5D334074CAB9]
http://linked.open...i/riv/nazevZdroje	Experimental Dermatology
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	5 (xsd:int)
http://linked.open...cetTvurcuVysledku	11 (xsd:int)
http://linked.open...vavai/riv/projekt	Mouse models for investigation of biological functions of novel Kazal-type protease inhibitors LEKTI-2 and LEKTI-3
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	20
http://linked.open...iv/tvurceVysledku	Sedláček, Radislav Brauer, Rena Buryová, Halka Dimitrieva, O. Fischer, J. Křenek, Pavel Meyer-Hoffert, U. Reiss, K. Sperrhacke, M. Suchanová, Šárka Wu, Z.
http://linked.open...ain/vavai/riv/wos	000296616200006
http://linked.open...n/vavai/riv/zamer	Molekulárně genetické a buněčné základy klíčových biologických procesů: genová exprese, onkogeneze, replikace virů, imunita a vývoj organismů
issn	0906-6705
number of pages	6 (xsd:int)
http://bibframe.org/vocab/doi	10.1111/j.1600-0625.2011.01355.x

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